| 曹铭晨,张泽南,肖忠伟,等.复发性阿弗他溃疡与口腔菌群微环境紊乱关系的研究进展[J].中国临床保健杂志,2025,28(5):713-717. |
| 复发性阿弗他溃疡与口腔菌群微环境紊乱关系的研究进展 |
| Research progress on the relationship between recurrent aphthous ulcers and oral microbiome homeostasis |
| 投稿时间：2025-06-23 |
| DOI：10.3969/J.issn.1672-6790.2025.05.025 |
| 中文关键词: 口炎,口疮性 口腔溃疡 生态失调 综述 |
| 英文关键词: Stomatitis,aphthous Oral ulcer Dysbiosis Review 〖FL |
| 基金项目:山东省医药卫生科技项目(202302021683)；山东省中医药科技发展项目(Q-2023204)；山东省青岛市中医药科技项目(2021-zyyq22) |
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| 中文摘要: |
| 复发性阿弗他溃疡(RAU)作为最常见的口腔黏膜疾病,其反复发作的特征严重影响患者生活质量,但发病机制至今尚未完全阐明。近年研究发现,口腔菌群稳态失衡可能通过免疫调节、代谢产物分泌及黏膜屏障破坏等多重途径参与RAU病理过程。本文从微生物学视角阐释了RAU发病机制,为临床开发基于菌群调控的靶向治疗策略提供参考。 |
| 英文摘要: |
| Recurrent aphthous ulceration (RAU) is the most common oral mucosal disease,and its recurrent nature severely affects the quality of life of patients.However,the pathogenesis remains not fully elucidated.Recent studies have found that the imbalance of oral microbiota homeostasis may participate in the pathological process of RAU through multiple pathways,including immune regulation,secretion of metabolic products,and disruption of the mucosal barrier.This article elucidates the pathogenesis of RAU from a microbiological perspective in order to provide a reference for the clinical development of targeted therapeutic strategies based on microbiota regulation. |
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