| 孙雪林,李婷,付春毅,等.莱博雷生治疗失眠的快速卫生技术评估[J].中国临床保健杂志,2025,28(6):769-775. |
| 莱博雷生治疗失眠的快速卫生技术评估 |
| A rapid health technology assessment of Lemborexant for insomnia |
| 投稿时间：2025-11-11 |
| DOI：10.3969/J.issn.1672-6790.2025.06.009 |
| 中文关键词: 莱博雷生 失眠症 双食欲素受体拮抗剂 有效性 安全性 经济性 快速卫生技术评估 |
| 英文关键词: Lemborexant Insomnia Dual orexin receptor antagonist Effectiveness Safety Economic efficiency Rapid health technology assessment 〖FL |
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| 摘要点击次数: 36 |
| 全文下载次数: 21 |
| 中文摘要: |
| 目的 评价莱博雷生治疗失眠的有效性、安全性和经济性。方法 检索PubMed、The Cochrane Library、中国知网、万方数据知识服务平台、维普网及卫生技术评估(HTA)相关网站,收集莱博雷生治疗失眠的系统评价/Meta分析、药物经济学研究和HTA报告,经资料提取、质量评价后,对纳入研究的结果进行描述性分析。结果 共纳入17篇文献,包括16篇系统评价/Meta分析和1篇药物经济学研究。在有效性方面,与安慰剂相比,莱博雷生可降低持续睡眠潜伏期、入睡后觉醒时间、失眠严重指数、入睡潜伏期,提高睡眠效率和延长总睡眠时间(P＜0.05)。在安全性方面,除嗜睡发生风险莱博雷生高外(P＜0.05),在治疗期间出现的不良事件、导致治疗中止的治疗期间出现的不良事件(TEAE)、严重TEAE和不良事件发生风险上,莱博雷生和安慰剂差异无统计学意义(P＞0.05)。结论 莱博雷生治疗失眠的效果显著,安全性高。 |
| 英文摘要: |
| Objective To evaluate the effectiveness,safety,and economic efficiency of lemborexant in the treatment of insomnia.Methods PubMed,The Cochrane Library,CNKI,Wanfang Database,VIP,and health technology assessment (HTA) websites were searched to collect systematic reviews/meta-analyses,pharmacoeconomic studies,and HTA reports on lemborexant for insomnia.After data extraction and quality assessment,a descriptive analysis was conducted on the results of the included studies.Results A total of 17 articles were included,comprising 16 systematic reviews/meta-analyses and one pharmacoeconomic study.In terms of effectiveness,compared with placebo,lemborexant significantly reduced latency to persistent sleep,wake time after sleep onset,insomnia severity index,and sleep onset latency,and significantly increased sleep efficiency and total sleep time (P<0.05).Regarding safety,except for the significantly higher risk of somnolence with lemborexant (P<0.05) had no significant differences in treatment-emergent adverse events (TEAE),TEAE leading to discontinuation,serious TEAE,or the overall risk of adverse events between lemborexant and placebo,suvorexant (P>0.05).Conclusions Lemborexant is effective and safe in the treatment of insomnia. |
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