| 郑丽,刘德军,张卫娜,等.1990年至2021年中国与全球糖尿病肾病负担趋势的分析与比较[J].中国临床保健杂志,2025,28(6):804-811. |
| 1990年至2021年中国与全球糖尿病肾病负担趋势的分析与比较 |
| Analysis and comparison of the trends in burden of diabetic kidney disease in China and worldwide from 1990 to 2021 |
| 投稿时间：2025-10-24 |
| DOI：10.3969/J.issn.1672-6790.2025.06.014 |
| 中文关键词: 糖尿病肾病 患病代价 发病率 患病率 病死率 伤残调整寿命年 |
| 英文关键词: Diabetic nephropathies Cost of illness Incidence Prevalence Mortality Disability-adjusted life years 〖FL |
| 基金项目:军队后勤科研项目(20BJZ47);首都卫生发展科研专项(首发2022-3-6111) |
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| 中文摘要: |
| 目的 分析1990—2021年中国糖尿病肾病流行情况、疾病负担和变化趋势,并将其与全球相关状况进行比较,为糖尿病肾病的防控提供参考依据。方法 基于2021年全球疾病负担(GBD)数据库的开放数据,分析中国和全球糖尿病肾病的疾病负担特征,包括发病率、患病率、病死率和伤残调整生命年(DALY)的变化。并利用Joinpoint模型计算年度变化百分比(APC)和平均年度变化百分比(AAPC),以反映糖尿病肾病负担的趋势。最后分年龄段比较中国和全球糖尿病肾病负担差异。结果 1990—2021年中国1型糖尿病肾病的发病率和DALY分别减少33.3%和3.35%,但是患病率和病死率分别上升97.37%和6.33%；2型糖尿病肾病的发病率、患病率、病死率和DALY分别增长177.6%、75.87%、147.3%和106.01%。全球不同类型糖尿病肾病的发病率、患病率、病死率和DALY均呈现增长趋势。1990—2021年中国1型糖尿病肾病患者年龄标化发病率、年龄变化患病率、年龄标化病死率和年龄标化DALY的AAPC均呈现下降趋势；2型糖尿病肾病患者年龄标化发病率、年龄变化患病率的AAPC呈上升趋势,年龄标化病死率和年龄标化DALY的AAPC呈现下降趋势。年龄对糖尿病肾病负担的影响不同,2型糖尿病肾病病死率和DALY随着年龄的增长而增长,其他的变化通常随年龄的增长呈现先上升后下降的趋势。结论 糖尿病肾病有着沉重的疾病负担,特别是2型糖尿病肾病,其疾病负担要高于1型。老年人群糖尿病肾病的病死率更高。 |
| 英文摘要: |
| Objective To analyze the prevalence,disease burden,and changing trends of diabetic kidney disease (DKD) in China from 1990 to 2021,and compare them with the global situation to provide a reference for the prevention and control of DKD.Methods Based on the open data from the 2021 Global Burden of Disease (GBD) database,analyze the characteristics of the disease burden of DKD in China and globally,including changes in incidence,prevalence,mortality,and disability-adjusted life years (DALY).Use the Joinpoint model to calculate the annual percentage change (APC) and the average annual percentage change (AAPC) to reflect the trends in the burden of DKD.Finally,conduct a comparative analysis of the differences in the burden of DKD between China and the world by age groups.Results From 1990 to 2021,the incidence and DALY of type 1 DKD in China decreased by 33.3% and 3.35% respectively,but the prevalence and mortality increased by 97.37% and 6.33% respectively.The incidence,prevalence,mortality,and DALY of type 2 DKD increased by 177.6%,75.87%,147.3%,and 106.01% respectively.The incidence,prevalence,mortality,and DALY of different types of DKD globally showed an increasing trend.From 1990 to 2021,the AAPC of ASIR,ASPR,ASMR,and ASDR of type 1 DKD patients in China showed a downward trend.The AAPC of ASIR and ASPR of type 2 DKD patients showed an upward trend,while the AAPC of ASMR and ASDR showed a downward trend.Age had different effects on the burden of DKD.The mortality and DALY of type 2 DKD increased with age,while other changes generally showed a trend of first increasing and then decreasing with age.Conclusions The burden of DKD is relatively heavy,and the disease burden of type 2 DKD is higher than that of type 1.The mortality rate of DKD among the elderly is higher. |
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