| 谢梁震,夏晴,马锐,等.小檗碱对多囊卵巢综合征患者糖脂代谢紊乱的影响[J].中国临床保健杂志,2025,28(6):823-827. |
| 小檗碱对多囊卵巢综合征患者糖脂代谢紊乱的影响 |
| The effect of berberine on glucose and lipid metabolism disorders in polycystic ovary syndrome |
| 投稿时间：2025-02-21 |
| DOI：10.3969/J.issn.1672-6790.2025.06.017 |
| 中文关键词: 多囊卵巢综合征 小檗碱 糖脂代谢 激素 |
| 英文关键词: Polycystic ovary syndrome Berberine Glycolipid metabolism Testosterone 〖FL |
| 基金项目:中国中医科学院学部委员学术传承与传播专项(CI2022E007XB)；北京中医药大学重点攻关项目(2020-JYB-ZDGG-131)；黑龙江中医药大学科研基金项目(201807) |
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| 中文摘要: |
| 目的 观察小檗碱对多囊卵巢综合征(PCOS)患者糖脂代谢紊乱的临床疗效。方法 选择2019年1月至2020年12月在黑龙江中医药大学附属第一医院妇科门诊就诊的77例PCOS患者,根据区组随机化方法分为小檗碱组(39例)和对照组(38例)。小檗碱组给予小檗碱,500 mg/次,3次/d；对照组给予二甲双胍,500 mg/次,3次/d；均治疗6个月。记录观察体重指数(BMI)、腰围、臀围和腰臀比；空腹血糖、空腹胰岛素、胰岛素抵抗指数(HOMA-IR)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)；卵泡生长激素(FSH)、促黄体生成激素(LH)、LH/FSH、雌二醇(E2)、睾酮(T)。结果 治疗后,2组患者BMI、腰围、臀围和腰臀比较治疗前均降低,血清空腹血糖、空腹胰岛素、HOMA-IR、TG、TC、LDL-C、LH、FSH、LH/FSH、E2、T水平较治疗前显著下降,HDL-C水平较治疗前升高,差异有统计学意义(P<0.05)；与对照组相比,小檗碱组PCOS患者臀围较小,同时改善HOMA-IR、TG、TC、HDL-C、LDL-C、LH、LH/FSH、E2、T的水平,差异有统计学意义(P<0.05)。结论 小檗碱可有效改善PCOS患者糖脂代谢紊乱,调控PCOS患者激素水平。 |
| 英文摘要: |
| Objective To observe the clinical efficacy of berberine in improving glucose and lipid metabolism disorders in polycystic ovary syndrome (PCOS).Method There were 77 PCOS patients who visited the outpatient department of the First Affiliated Hospital of Heilongjiang University of Chinese Medicine from January 2019 to December 2020.They were randomly divided into berberine group(n=39) and control group(n=38) based on block randomization.The berberine group was given berberine 500 mg three times a day,while the control group was given metformin 500 mg three times a day for a total of 6 months.Body Mass Index(BMI),waist circumference,hip circumference,and waist to hip ratio,fasting blood glucose,fasting insulin,insulin resistance index (HOMA-IR),triglycerides (TG),total cholesterol (TC),low-density lipoprotein cholesterol (LDL-C),high-density lipoprotein cholesterol (HDL-C),follicle growth hormone (FSH),luteinizing hormone (LH),LH/FSH ratio,estradiol (E2),and testosterone (T) were recorded and observed.Results After treatment,the BMI,waist circumference,hip circumference,and waist to hip ratio of both groups of patients decreased (P<0.05),and serum Glucose,Insulin,HOMA-IR,TG,TC,HDL-C,LDL-C,LH,FSH,LH/FSH,E2,and T levels decreased (P<0.05).Compared with the control group,the berberine group was able to reduce hip circumference and waist hip ratio,while improving HOMA-IR,TG,TC,HDL-C,LDL-C,LH,LH/FSH,E2,and T (P<0.05).Conclusions Berberine can effectively improve glucose and lipid metabolism disorders and hormone levels in PCOS. |
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