| 董亚苒,王宇,张润华,等.社区人群颅内动脉粥样硬化斑块形成的危险因素分析[J].中国临床保健杂志,2025,28(6):828-832. |
| 社区人群颅内动脉粥样硬化斑块形成的危险因素分析 |
| Risk factors associated with the formation of intracranial atherosclerotic plaques in a community-based population |
| 投稿时间：2025-07-11 |
| DOI：10.3969/J.issn.1672-6790.2025.06.018 |
| 中文关键词: 颅内动脉粥样硬化斑块 危险因素 社区人群 横断面研究 |
| 英文关键词: Intracranial arteriosclerosis plaque Risk factors Community-based population Cross-sectional studies 〖FL |
| 基金项目:北京市科技计划重大项目(D131100002313002) |
| 作者 | 单位 | E-mail | | 董亚苒 | 首都医科大学石景山教学医院 北京石景山医院,综合科,北京 100040 | liugaifen1997@163.com | | 王宇 | 首都医科大学附属北京天坛医院,北京市脑血管疾病防治办公室,北京 100070
浙江省人民医院神经内科,杭州 310014 | liugaifen1997@163.com | | 张润华 | 首都医科大学附属北京天坛医院,北京市脑血管疾病防治办公室,北京 100070 | liugaifen1997@163.com | | 秦海强 | 首都医科大学附属北京天坛医院,神经病学中心,北京 100070 | liugaifen1997@163.com | | 王新芳 | 首都医科大学石景山教学医院 北京石景山医院,老年医学科,北京 100040 | liugaifen1997@163.com | | 赵锡海 | 清华大学医学院生物医学工程学院,生物医学影像研究中心,北京 100084 | liugaifen1997@163.com | | 刘改芬 | 首都医科大学附属北京天坛医院,北京市脑血管疾病防治办公室,北京 100070 | liugaifen1997@163.com |
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| 中文摘要: |
| 目的 探讨社区人群颅内动脉粥样硬化斑块形成的相关危险因素。方法 在清华大学社区招募研究对象,于2015年5月至2017年2月期间完成高分辨磁共振成像(HR-MRI)检查者纳入本研究。采用横断面调查,通过现场调查问卷获得人口统计学资料、既往病史、现病史、行为生活方式,以及体格检查、实验室检查等信息。根据磁共振成像检查评估颅内动脉粥样硬化斑块的分布情况,采用多因素logistic回归分析探讨与斑块形成相关的危险因素。结果 本研究共纳入511例研究对象,其中男201例(39.3%),年龄(60.0±13.8)岁。在511例研究对象中发现155例(30.3%)有颅内动脉粥样硬化斑块形成。 和无颅内动脉粥样硬化组相比,颅内斑块组年龄较高、男性较多、吸烟者较多、有高血压病史比例更高、糖尿病病史比例更高、房颤病史比例更高、收缩压更高、腰围更高,差异均有统计学意义(均P<0.05)。血液检测指标中,和无颅内动脉粥样硬化组相比,颅内斑块组空腹血糖、糖化血红蛋白和超敏C反应蛋白的水平较高,而总胆固醇和低密度脂蛋白的水平较低,差异均有统计学意义(均P<0.05)。由于年龄是不可控因素,在不纳入年龄的多因素logistic回归分析发现,既往高血压病史(OR=1.66,95%CI:1.05~2.63,P=0.03)和糖化血红蛋白的水平(OR=1.65,95%CI:1.07~2.53,P=0.02)是颅内动脉粥样硬化斑块形成的独立危险因素。 结论 年龄较大、既往高血压病史和糖化血红蛋白增高可能是颅内动脉粥样硬化斑块形成的危险因素。 |
| 英文摘要: |
| Objective To explore the risk factors of intracranial atherosclerotic plaque formation in community population.Methods Recruitment of research subjects in the Tsinghua University community,who completed high-resolution magnetic resonance imaging (HR-MRI) examinations between May 2015 and February 2017,were included in this study.A cross-sectional survey was conducted to obtain demographic,medical history,current medical history,behavioral lifestyle,physical examination,laboratory tests,and other information through on-site questionnaires.According to the measurement of HR-MRI,the formation of intracranial carotid artery plaques in carotid artery were evaluated.Univariate and Multivariate logistic regression analysis was used to investigate the independent risk factors associated with plaque formation.Results Among 511 subjects,there were 201 (39.3%) males and the average age was (60.0±13.8) years.In the 511 subjects with clear intracranial image,155 cases (30.3%) were diagnosed with intracranial plaques. Compared with the group without intracranial atherosclerosis,the intracranial plaque group had a higher age,a higher proportion of males,a higher proportion of smokers,a higher proportion with a history of hypertension,a higher proportion with a history of diabetes,a higher proportion with a history of atrial fibrillation,a higher systolic blood pressure,and a higher waist circumference,with statistically significant differences (all P<0.05).Among the blood test indicators,compared with the group without intracranial atherosclerosis,the intracranial plaque group had higher levels of fasting blood glucose,glycosylated hemoglobin,and high-sensitivity C-reactive protein,while the levels of total cholesterol and low-density lipoprotein were lower,with statistically significant differences (all P<0.05).Since age is an uncontrollable factor,a multi-factor logistic regression analysis excluding age revealed that a history of previous hypertension (OR=1.66,95%CI:1.05-2.63,P=0.03) and the level of glycated hemoglobin (OR=1.65,95%CI:1.07-2.53,P=0.02) are independent risk factors for the formation of intracranial atherosclerotic plaques. Conclusions Age,previous history of hypertension,and HbA1c levels may be risk factors for intracranial atherosclerotic plaque formation. |
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