| 王雨濛,彭文举,夏百荣.妇科肿瘤化疗相关认知障碍的研究进展[J].中国临床保健杂志,2025,28(6):850-854. |
| 妇科肿瘤化疗相关认知障碍的研究进展 |
| Research advances in the diagnosis and management of chemotherapy-induced cognitive impairment in gynaecological oncology |
| 投稿时间：2025-09-22 |
| DOI：10.3969/J.issn.1672-6790.2025.06.023 |
| 中文关键词: 生殖器肿瘤,女(雌)性 认知障碍 诊断技术和方法 药物疗法 综述 |
| 英文关键词: Genital neoplasms,female Cognition disorders Diagnostic techniques and procedures Drug therapy Review 〖FL |
| 基金项目:国家自然科学基金项目(82404092) |
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| 摘要点击次数: 36 |
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| 中文摘要: |
| 妇科肿瘤化疗相关认知障碍(CICI)是影响患者生存质量的重要并发症,其发生率为70%,涉及多因素交互作用。生物学机制包括化疗药物直接神经毒性,通过诱发神经炎症、氧化应激及血脑屏障破坏损伤海马体和前额叶认知功能区；妇科肿瘤特有的雌激素水平骤降进一步削弱神经保护作用,加剧神经元损伤。心理社会因素中,焦虑、抑郁及疲乏与CICI呈负相关,且教育水平低、高龄及共病状态可加重认知损害。干预研究显示,靶向髓鞘再生的药物和基于家庭的认知训练可改善认知功能。本综述总结了妇科肿瘤CICI的发病机制和诊疗进展,以期为准确识别与诊断该类人群的认知障碍、优化临床管理以及研发针对性的治疗新方案提供参考。 |
| 英文摘要: |
| Chemotherapy-induced cognitive impairment (CICI) in gynaecological oncology patients is an important complication that affects the survival quality of patient,with an incidence of 70%,and involves multifactorial interactions.Biological mechanisms include direct neurotoxicity of chemotherapeutic drugs,which damages hippocampal and prefrontal cognitive regions by inducing neuroinflammation,oxidative stress and blood-brain barrier disruption,and the gynecological tumour-specific plunge in oestrogen levels,which further weakens neuroprotection and exacerbates neuronal damage.Among the psychosocial factors,anxiety,depression and fatigue were significantly negatively correlated with CICI,and cognitive impairment was exacerbated by low education level,advanced age and co-morbidities.Intervention studies have shown that drugs targeting myelin regeneration and home-based cognitive training can improve cognitive function.This review summarizes the pathogenesis and diagnostic and therapeutic progress of CICI in gynecological tumors,aiming to provide reference for accurately identifying and diagnosing cognitive impairments in this population,optimizing clinical management,and developing targeted treatment plans |
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