| 肖敏,李敏,丁秀芳,等.超敏C反应蛋白水平与衰弱和冠心病的相关性研究[J].中国临床保健杂志,2026,(1):110-113. |
| 超敏C反应蛋白水平与衰弱和冠心病的相关性研究 |
| Study about the relationship between hypersensitive C-reactive protein level with frailty and coronary heart disease |
| 投稿时间：2025-07-08 |
| DOI：10.3969/J.issn.1672-6790.2026.01.019 |
| 中文关键词: 衰弱 冠心病 C反应蛋白质 危险因素 老年人 |
| 英文关键词: Frailty Coronary disease C-reactive protein Risk factors Aged 〖FL |
| 基金项目: |
|
| 摘要点击次数: 58 |
| 全文下载次数: 47 |
| 中文摘要: |
| 目的 探讨超敏C反应蛋白(hs-CRP)与冠心病和衰弱之间的关系,为改善其临床结局提供思路和干预靶点。方法 横断面调查选取2023年1月至2024年6月北京市隆福医院老年科≥60岁住院患者313例。根据是否有冠心病和衰弱状态将患者分为冠心病无衰弱组、冠心病合并衰弱组、无冠心病无衰弱组和无冠心病有衰弱组,比较4组患者的一般情况及hs-CRP情况。危险因素分析采用多元logistic回归分析。结果 313例患者年龄(73.5±8.0)岁,男性133例,女性180例。其中冠心病无衰弱组56例,冠心病并衰弱组36例,无冠心病无衰弱组163例,无冠心病有衰弱组58例。住院老年患者中冠心病发生率为29.4%,衰弱发生率为30.0%,而冠心病患者中衰弱发生率为39.1%,衰弱人群中冠心病的占比为38.3%。无论是否有冠心病,衰弱人群比非衰弱人群的年龄更大(P<0.05)。hs-CRP与冠心病没有相关性(P>0.05),而与衰弱有相关性(P<0.05)。hs-CRP诊断衰弱的受试者操作特征曲线下面积为0.709(P<0.001),其灵敏度74.0%,特异度65.4%,最佳预测阈值为2.69 mg/L。结论 年龄是冠心病和衰弱的共同危险因素,冠心病与衰弱有关联性。排除混杂因素后,hs-CRP是衰弱的危险因素,其预测衰弱的ROC曲线最佳临界值为2.69 mg/L。 |
| 英文摘要: |
| Objective To explore the relationship between high-sensitivity C-reactive protein (hs-CRP) and patients with coronary heart disease (CHD) and frailty,providing ideas and intervention targets to improve adverse factors.Methods A cross-sectional survey was conducted selecting 313 inpatients aged ≥60 years from the Geriatrics Department of Longfu Hospital,Beijing,from January 2023 to June 2024.Patients were divided into four groups based on the presence of CHD and frailty:CHD without frailty,CHD with frailty,no CHD without frailty,and no CHD with frailty.The general conditions and hs-CRP levels of the four groups were compared.Multivariate logistic regression analysis was used to identify risk factors.Results The 313 patients had a mean age of (73.5±8.0) years,including 133 males and 180 females.Among them,there were 56 cases in the CHD without frailty group,36 in the CHD with frailty group,163 in the no CHD without frailty group,and 58 in the no CHD with frailty group.Among hospitalized elderly patients,the prevalence of CHD was 29.4% and the prevalence of frailty was 30.0%,while the prevalence of frailty among CHD patients was 39.1%,and the proportion of CHD in the frail population was 38.3%.Regardless of the presence of CHD,the frail population was older than the non-frail population (P<0.05).Hs-CRP was not associated with CHD (P>0.05) but was associated with frailty (P<0.05).The ROC curve for hs-CRP had an area under the curve of 0.709 (P<0.001),with a sensitivity of 74.0%,specificity of 65.4%,and the optimal predictive threshold of 2.69 mg/L.Conclusions Age is a common risk factor for both CHD and frailty,and CHD is associated with frailty.After excluding confounding factors,hs-CRP is a risk factor for CHD,and the optimal cutoff value of its ROC curve for predicting frailty is 2.69 mg/L. |
|
查看全文
|
| 关闭 |
|
|
|