| 姚红萍,李玉华,满慧慧,等.皮肤晚期糖基化蛋白产物测定在糖尿病肾脏病诊断中的价值[J].中国临床保健杂志,2026,(1):122-126. |
| 皮肤晚期糖基化蛋白产物测定在糖尿病肾脏病诊断中的价值 |
| Value of skin advanced glycation end products determination for screening diabetic kidney disease |
| 投稿时间：2026-01-10 |
| DOI：10.3969/J.issn.1672-6790.2026.01.021 |
| 中文关键词: 糖尿病肾脏病 糖基化 皮肤生理学现象 诊断技术,内分泌 |
| 英文关键词: Diabetic kidney disease Glycosylation Skin physiological phenomena Diagnostic techniques,endocrine Fund program:National Natural Science Foundation of China |
| 基金项目:国家自然科学基金项目 |
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| 中文摘要: |
| 目的 探讨测定皮肤晚期糖基化蛋白产物(AGE)对糖尿病肾脏病(DKD)的诊断价值及其最佳截点值。方法 采用回顾性横断面调查。选取2025年1—5月安徽省某三甲医院内分泌科收治的141例2型糖尿病(T2DM)住院患者作为研究对象。采用自行设计的问卷收集一般资料,并对患者AGE、血清学及尿液相关指标进行测定,根据尿白蛋白/肌酐比值(UACR)分为DKD组和单纯T2DM组。根据受试者操作特征(ROC)曲线的灵敏度、特异度及约登指数,确定利用AGE筛查DKD的最佳截断值。结果 141例T2DM患者中,DKD的患病率为41.8%,DKD组患者的年龄、糖尿病病程、UACR和AGE均显著高于单纯T2DM组(均P＜0.05)。AGE筛查DKD的ROC曲线下面积为0.680(P＜0.001),最佳截断值为82.1 AU(灵敏度:67.8%,特异度:64.4%)。≥60岁的糖尿病患者AGE[(87.28±12.93)AU]显著高于<60岁的人群[(76.47±11.83)AU],差异有统计学意义(P＜0.001)；糖尿病病程≥5年者AGE[(85.56±12.49)AU]显著高于糖尿病病程＜5年者[(72.65±12.06)AU],差异有统计学意义(P＜0.001)。糖尿病病程≥5年者,AGE筛查DKD的最佳截断值为80.5 AU(灵敏度:78.4%,特异度:55.4%)。结论 检测皮肤AGE可有效预测T2DM患者发生DKD,尤其是对于≥60岁或糖尿病病程≥5年患者。 |
| 英文摘要: |
| Objective To determine the diagnostic value and optimal cut-off value of skin advanced glycation end products (AGE) determination for screening diabetic kidney disease (DKD).Methods We conducted a retrospective cross-sectional study.A total of 141 inpatients with type 2 diabetes mellitus (T2DM) admitted to the endocrinology department of a tertiary hospital in Anhui Province from January to May 2025 were selected.General information was collected using a self-designed questionnaire,and AGE determination,serological and urine-related index determination were conducted for the patients.Patients were divided into DKD group and simple T2DM group acorrding to the UACR.Based on the sensitivity and specificity of each point on the Receiver Operating Characteristic curve (ROC) and the YouDen Index,the optimal cut-off value for AGE screening of DKD was determined.Results Among the 141 T2DM patients,the prevalence of DKD was 41.8%.The age,duration of diabetes,urine albumin (UALB),and AGE of the DKD group were significantly higher than those of the simple T2DM group (all P<0.05).The AUC of AGE for screening DKD was 0.680 (P<0.001),and the optimal cut-off value was 82.1 AU (sensitivity:67.8%,specificity:64.4%).The AGE level of diabetic patients over 60 years old [(87.28±12.93)AU] was significantly higher than that of the population under 60 years old [(76.47±11.83)AU],P<0.001;the AGE [(85.56±12.49)AU] in patients with diabetes for ≥5 years was significantly higher than that in the population with a disease duration of<5 years [(72.65±12.06)AU],P<0.001.For diabetic patients with a duration of diabetes of ≥5 years,the optimal cut-off value of AGE for screening DKD was 80.5 AU (sensitivity:78.4%,specificity:55.4%).Conclusions Detecting skin AGE can effectively predict the development of DKD in T2DM patients,especially for those aged over 60 or with a disease duration of ≥5 years. |
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