| 王琼,张虹,胡晓琴,等.三酰甘油-葡萄糖指数及其衍生指数对冠心病患者冠状动脉病变严重程度的预测价值[J].中国临床保健杂志,2026,29(3):354-358. |
| 三酰甘油-葡萄糖指数及其衍生指数对冠心病患者冠状动脉病变严重程度的预测价值 |
| Predictive value of triacylglycerol-glucose and triacylglycerol-glucose-body mass index for severity of coronary artery lesions in patients with coronary artery disease |
| 投稿时间：2025-11-08 |
| DOI：10.3969/J.issn.1672-6790.2026.03.011 |
| 中文关键词: 冠心病 冠状动脉疾病 三酰甘油 葡萄糖 体重指数 |
| 英文关键词: Coronary disease Coronary artery disease Triacylglycerol Glucose Body mass index 〖FL |
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| 中文摘要: |
| 目的 探讨三酰甘油-葡萄糖(TyG)指数及其衍生指数三酰甘油-葡萄糖-体重指数(TyG-BMI)对冠心病(CHD)患者冠状动脉病变严重程度的预测价值。方法 回顾性分析2023年1月至2024年1月在山西医科大学第五临床医学院(山西省人民医院)心内科就诊的351例住院患者临床资料。所有患者均行冠脉造影检查,根据检查结果分为CHD组(210例)和对照组(141例)；以Gensini积分评估CHD患者冠脉病变程度,分为轻中度病变组(Gensini评分≤20分,111例)和重度病变组 (Gensini评分>20分,99例)。计算TyG指数和TyG-BMI,并分析其与CHD及冠脉病变程度的关系。构建logistic回归模型并绘制受试者操作特征(ROC)曲线,评估TyG指数及TyG-BMI对冠脉病变程度的预测价值。结果 CHD组TyG指数和TyG-BMI均高于对照组(均P<0.05)；轻中度病变组TyG指数、TyG-BMI、Gensini评分均低于重度病变组(均P<0.05)；调整混杂因素后,多因素logistic回归分析显示,基线TyG四分位数Q2组、Q3组、Q4组患重度病变的风险分别是Q1组的2.875倍、4.457倍、5.633倍(P趋势<0.001)；基线TyG-BMI四分位数Q2组、Q3组、Q4组患重度病变的风险分别是Q1组的1.990倍、4.850倍、7.803倍(P趋势<0.001)。TyG指数及TyG-BMI预测重度冠脉病变程度的AUC面积分别为0.705、0.725,最佳截断值分别为7.220、194.800。结论 TyG、TyG-BMI的高水平状态都是CHD患者冠脉病变严重程度的独立危险因素,对冠脉病变严重程度具有一定的预测价值。 |
| 英文摘要: |
| Objective To investigate the predictive value of the triacylglycerol-glucose (TyG) index and its derivative index,triacylglycerol-glucose-body mass index (TyG-BMI),on the severity of coronary artery lesions in patients with coronary heart disease (CHD).Methods The clinical data of 351 hospitalized patients who visited the Department of Cardiology at Shanxi Provincial People′s Hospital from January 2023 to January 2024 was analyzed.All of whom underwent coronary angiography were divided into the CHD group (n=210) and the control group (n=141) according to the results of the examination;the degree of coronary artery lesions in patients with CHD was assessed by the Gensini score,and they were divided into the group of mild-to-moderate lesions (Gensini score ≤20 points,n=111) and severe lesion group (Gensini score>20 points,n=99).After admission,the relevant data of patients were collected,TyG index and TyG-BMI were calculated and analyzed in relation to the degree of CHD and coronary artery lesions,and logistic regression model was constructed and subjects′ work characteristic curve (ROC) curve was plotted to assess the predictive value of TyG index and TyG-BMI on the degree of coronary artery lesions.Results TyG index and TyG-BMI were higher in the CHD group than those in the control group (P<0.05).TyG index,TyG-BMI,and Gensini score were lower in the mild-to-moderate lesion group than in the severe lesion group (P<0.05).After adjusting for confounders,multifactorial logistic regression analysis showed that the baseline TyG quartiles of group Q2,Q3,and Q4 had a lower risk of developing severe lesions were 2.875,4.457,and 5.633 times higher than those in group Q1,respectively (Ptrend<0.001);and the risk of developing severe lesions in baseline TyG-BMI quartiles groups Q2,Q3,and Q4 was 1.990,4.850,and 7.803 times higher than that in group Q1,respectively (Ptrend<0.001).The TyG Index and TyG-BMI Predicted the AUC area of the degree of severe coronary lesions were 0.705 and 0.725,respectively,and the optimal cutoff values were 7.220 and 194.800,respectively.Conclusions The high level TyG index and TyG-BMI both are an independent risk factor for the severity of coronary lesions in patients with CHD and have a certain predictive value of the degree of coronary lesion severity,whereas the predictive value of TyG-BMI is better than that of the TyG index,and TyG-BMI has better predictive value than TyG index. |
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