| 张梦媛,邢燕,李红旗.高龄心力衰竭住院患者1年内死亡的危险因素分析[J].中国临床保健杂志,2026,29(3):359-363. |
| 高龄心力衰竭住院患者1年内死亡的危险因素分析 |
| Analysis of risk factors for 1-year mortality in very old hospitalized patients with heart failure |
| 投稿时间：2025-09-10 |
| DOI：10.3969/J.issn.1672-6790.2026.03.012 |
| 中文关键词: 心力衰竭 死亡 危险因素 老年人,80岁及以上 |
| 英文关键词: Heart failure Death Risk factors Aged,80 and over Fund program:Key Natural Science Research Project of Universities in Anhui Province |
| 基金项目:安徽省高校自然科学研究重点项目 |
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| 中文摘要: |
| 目的 探讨高龄心力衰竭住院患者1年内全因死亡的危险因素,为个体化预后评估和临床管理提供参考。方法 回顾性分析2021年1月至2024年4月在中国科学技术大学附属第一医院(安徽省立医院)住院治疗的115例年龄≥80岁心力衰竭患者的临床资料。根据1年内生存状态分为死亡组和存活组,比较两组基线资料、合并疾病、检验检查指标及出院用药情况。采用单因素分析筛选候选变量,并进一步采用多因素logistic回归分析1年内全因死亡的相关因素。结果 115例高龄心力衰竭患者中,1年内死亡25例。多因素logistic回归分析显示,增龄(OR=1.141,95%CI:1.016~1.281)、合并冠心病(OR=3.158,95%CI:1.075~9.276)和N末端B型利尿钠肽原≥6 000 ng/L(OR=6.988,95%CI:2.339~20.873)是高龄心力衰竭患者1年内全因死亡的独立危险因素,使用钠-葡萄糖协同转运蛋白2抑制剂是保护因素(OR=0.171,95%CI:0.032~0.918)。结论 在高龄心力衰竭住院患者中,年龄、冠心病、N末端B型利尿钠肽原水平及钠-葡萄糖协同转运蛋白2抑制剂使用情况与1年内全因死亡相关,这些指标可为高龄心力衰竭患者的风险分层和临床管理提供参考。 |
| 英文摘要: |
| Objective To investigate the risk factors for 1 year all cause mortality in very old hospitalized patients with heart failure,and to provide reference for individualized prognostic assessment and clinical management.Methods Clinical data of 115 patients aged ≥80 years who were hospitalized with heart failure in the the First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital) from January 2021 to April 2024 were retrospectively analyzed.According to survival status within 1 year,patients were divided into a death group and a survival group.Baseline characteristics,comorbidities,laboratory and examination findings,and discharge medications were compared between the two groups.Candidate variables were screened by univariate analysis,and multivariate Logistic regression was used to analyze factors associated with 1 year all cause mortality.Results Among the 115 very old patients with heart failure,25 died within 1 year.Multivariate Logistic regression analysis showed that advanced age (OR=1.141,95%CI:1.016-1.281),coronary artery disease (OR=3.158,95%CI:1.075-9.276),and N-terminal pro-B-type natriuretic peptide ≥ 6 000 ng/L (OR=6.988,95%CI:2.339-20.873) were independent risk factors for 1 year all cause mortality,while use of sodium-glucose cotransporter 2 inhibitors was a protective factor (OR=0.171,95%CI:0.032-0.918),all P<0.05.Conclusion In very old hospitalized patients with heart failure,age,coronary artery disease,N-terminal pro-B-type natriuretic peptide level,and sodium-glucose cotransporter 2 inhibitors use are associated with 1-year all-cause mortality.These indicators may provide reference for risk stratification and clinical management in this population. |
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