| 王胜文,季学磊,姚兰,等.估计葡萄糖处置率与老年2型糖尿病患者并发高尿酸血症的关联性[J].中国临床保健杂志,2026,29(3):387-391. |
| 估计葡萄糖处置率与老年2型糖尿病患者并发高尿酸血症的关联性 |
| Association between estimated glucose disposal rate and hyperuricemia in elderly patients with type 2 diabetes mellitus |
| 投稿时间：2026-01-26 |
| DOI：10.3969/J.issn.1672-6790.2026.03.018 |
| 中文关键词: 糖尿病,2型 高尿酸血症 葡萄糖 危险因素 老年人 |
| 英文关键词: Diabetes mellitus,type 2 Hyperuricemia Glucose Risk factors Aged Fund programs:Construction Project of Key Clinical Specialties under Provincial Administration and Municipal Construction in Anhui Province |
| 基金项目:安徽省2024—2025年度省管市建临床重点专科建设项目 |
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| 中文摘要: |
| 目的 探讨估计葡萄糖处置率(eGDR)与老年2型糖尿病(T2DM)患者合并高尿酸血症(HUA)的关联性。方法 回顾性分析2024年12月至2025年12月华东师范大学附属芜湖医院(芜湖市第二人民医院)收治的452例老年T2DM患者临床资料。根据血尿酸(SUA)水平将患者分为高尿酸血症组(HUA组,137例)和尿酸正常组(NUA组,315例)。计算患者的eGDR值,比较两组患者的一般临床资料及生化指标。采用单因素及多因素logistic回归分析老年T2DM患者伴发HUA的独立危险因素。结果 HUA组患者的体重指数(BMI)、腰围、收缩压、糖化血红蛋白(HbA1c)、三酰甘油(TG)及SUA水平均高于NUA组(均P<0.05),而eGDR水平低于NUA组(P<0.05)。随着eGDR水平升高,SUA水平呈下降趋势(P<0.05)。单因素logistic回归分析显示,BMI、性别、HbA1c、TG的升高是HUA发生的危险因素；而eGDR的升高是HUA发生的保护因素。多因素logistic回归分析显示,校正混杂因素后,eGDR降低仍是老年T2DM患者并发HUA的独立危险因素(OR=0.685,P<0.05)。结论 eGDR与老年T2DM患者的SUA水平呈负相关,低eGDR是合并HUA的独立危险因素。 |
| 英文摘要: |
| Objective To investigate the association between estimated glucose disposal rate (eGDR) and hyperuricemia (HUA) in elderly patients with type 2 diabetes mellitus (T2DM).Methods A retrospective analysis was conducted on the clinical data of 452 elderly patients with T2DM admitted to Wuhu Hospital Affiliated to East China Normal University (The Second People′s Hospital of Wuhu) between December 2024 and December 2025.According to serum uric acid (SUA) levels,patients were divided into a hyperuricemia group (HUA group,n=137) and a normouricemia group (NUA group,n=315).eGDR was calculated for all patients.General clinical characteristics and biochemical parameters were compared between the two groups.Univariate and multivariate logistic regression analyses were used to investigate independent risk factors for hyperuricemia (HUA) in elderly patients with type 2 diabetes mellitus (T2DM).Results Compared with the NUA group,patients in the HUA group had higher body mass index (BMI),waist circumference,systolic blood pressure,glycated hemoglobin (HbA1c),triglycerides (TG),and SUA levels (all P<0.05),while eGDR levels were lower (P<0.05).SUA levels showed a decreasing trend with increasing eGDR (P<0.05).Univariate logistic regression analysis showed that higher BMI,male sex,and higher HbA1c and triglyceride (TG) levels are risk factors for the development of hyperuricemia,while a higher estimated glucose disposal rate (eGDR) was a protective factor.Multivariate logistic regression analysis demonstrated that,after adjusting for confounding factors,decreased eGDR remained an independent risk factor for HUA in elderly patients with T2DM (OR=0.685, P<0.05).Conclusions eGDR is negatively correlated with serum uric acid levels in elderly patients with T2DM.Low eGDR is an independent risk factor for hyperuricemia. |
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