| 刘磊,刘健,万磊,纵瑞凯,曹云祥.中医药对血管新生相关信号通路的影响[J].中国临床保健杂志,2016,(3):315-318. |
| 中医药对血管新生相关信号通路的影响 |
| Effects of traditional Chinese medicine on angiogenesis related signaling pathway |
| 投稿时间：2016-02-17 |
| DOI：10.3969/J.issn.1672-6790.2016.03.031 |
| 中文关键词: 血管生成调节剂 新生血管化,生理性 信号传导 中草药 |
| 英文关键词: Angiogenesis modulating agents Neovascularization,physiologic Signal transduction Drugs,Chinese herbal〖FL |
| 基金项目:国家临床重点专科中医风湿病科建设项目(财社[2013]239号)；国家中医药重点学科中医痹病学建设项目(国中医药发[2009]30号)；“十二五”国家科技支撑计划项目(2012BAI26B02)；安徽省重点实验室建设项目(1306c083035); 安徽省科技计划项目(11010402170) |
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| 中文摘要: |
| 血管新生是机体常见的重要生理、病理过程,其过程涉及多种细胞、细胞因子及相关信号通路,多种疾病的发生发展均血管新生密切相关。细胞因子通过信号转导通路调节血管新生相关细胞的迁移、增殖、凋亡影响血管新生。近年来对血管新生机制的最新研究表明,VEGF通路、Notch通路、PTEN/PI3K/AKT通路、JAK/STAT通路参与调节血管新生。中医药可通过调节信号转导通路调节血管新生,在治疗以血管新生为主要病变基础的疾病上取得了一定成绩。 |
| 英文摘要: |
| Angiogenesis is a common and important process of physiological and pathological.The process involves a lot of cells,cytokines and related signaling pathways.The development of many diseases are closely related to angiogenesis.Cytokines can affect angiogenesis by signaling pathways to mediate migration,proliferation,apoptosis of angiogenesis-related cell.In recent years,new research about mechanism of angiogenesis shows that VEGF pathway,Notch pathway,PTEN/PI3K/AKTpathway,JAK/STAT pathway involved in regulating angiogenesis.Chinese medicine can be regulating angiogenesis by adjusting signal transduction pathways,and had made certain achievements in the treatment of angiogenesis-based diseases. |
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