| 刘芬芬,余海瀛,赵德宇,胡世莲,程民,徐婷娟,沈国栋.尿液巯基化合物检测在筛查子宫颈癌及癌前病变中的临床价值[J].中国临床保健杂志,2017,20(1):11-13. |
| 尿液巯基化合物检测在筛查子宫颈癌及癌前病变中的临床价值 |
| Clinical value of urine thiol detection in cervical cancer and precancerous lesion screening |
| 投稿时间：2016-06-21 |
| DOI：10.3969/J.issn.1672-6790.2017.01.004 |
| 中文关键词: 宫颈肿瘤 尿分析 巯基化合物 |
| 英文关键词: Uterine cervical neoplasms Urinalysis Sulfhydryl compounds〖FL |
| 基金项目:安徽省科技攻关项目(1301042094) ；安徽省自然科学基金面上项目(1408085MH167) |
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| 中文摘要: |
| 目的 探讨尿液巯基化合物检测作为子宫颈癌早期筛查手段的可行性。方法 收集144例就诊者尿液作为对照组,其中包括健康体检结果正常人员104例、阴道炎患者20例、人乳头瘤病毒(HPV)感染者20例；确诊子宫颈癌等妇科肿瘤患者的尿液标本107例作为研究组。取1 mL新鲜尿液作为标本,使用化学显色法对标本进行巯基化合物含量检测,并以宫颈活检的组织病理学为金标准,评价尿液中巯基含量检测在子宫颈癌筛查中的临床价值。结果 在研究组中阳性反应有98例,阳性率为91.6%；健康对照组中人员无阳性反应；阴道炎患者阳性反应有5例,阳性率为25%；HPV感染者阳性反应有12例,阳性率为60%；研究组与健康对照组之间尿液巯基检测阳性率差异有统计学意义(P<0.01)。结论 尿液中巯基化合物检测对子宫颈癌及癌前病变筛查具有较高的敏感度,该方法简便、快速,适用于子宫颈癌的早期筛查。 |
| 英文摘要: |
| Objective To investigate the feasibility of the content of urine thiol detection as an early screening method of cervical cancer.Methods Urine collected 144 cases of patients as control group,including the physical examination results 104 cases of normal people,vaginitis patients 20 cases and HPV infection 20 cases.And 107 cases with cervical cancer or other gynecological cancer were in the experimental group.The thiol content in urine was detected using chemical color testing method.The pathological result of cervical biopsy was as the gold standard to evaluate the clinical value of the urine thiol detection in the screening of cervical cancer.Results This method only needs 1mL sample of fresh urine and the detection procedure is simple and quick.The clinical results showed that there were 98 cases of positive reaction in the experimental group,and the positive rate was 91.6%.Whereas,physical examination results in control group normal persons without positive reaction.Vaginitis patients with positive reaction in 5 cases,positive rate is 25%.HPV infection positive reaction in 12 cases,positive rate was 60%.Data analysis showed that the difference between the two group was statistically significant (P<0.01).Conclusion The method of thiol detection in urine has a high sensitivity for cervical cancer and precancerous lesion screening and is characterized as a simple,rapid and economical method,and thus is suitable for early screening of cervical cancer. |
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