| 郑延松,韩超进,陈志来,曾强.氢气对男性高尿酸血症治疗效果的研究[J].中国临床保健杂志,2017,20(2):118-121. |
| 氢气对男性高尿酸血症治疗效果的研究 |
| A study on the effect of hydrogen on the hyperuricemia in males |
| 投稿时间：2017-01-10 |
| DOI：10.3969/J.issn.1672-6790.2017.02.002 |
| 中文关键词: 高尿酸血症 男(雄)性 氢 |
| 英文关键词: Hyperuricemia Male Hydrogen〖FL |
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| 中文摘要: |
| 目的 探讨氢气对高尿酸血症的疗效。方法 采用随机对照双盲法,将确诊为高尿酸血症的男性患者分为试验组和对照组。试验组:生活方式干预配合服用溶解了氢气的水(浓度为1.0~1.5 mg/L)调理,每次200 mL,每日3次；对照组:生活方式干预配合服用不加氢气的安慰剂水,剂量相同。干预时间为3个月。记录干预前后患者年龄、血压、总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、空腹血糖、血尿酸、血肌酐和尿素等实验室检查,自我感觉评定及亚健康状况测评。结果 揭盲后,试验组实际参与40例,完成37例,脱失3例(7.50%)；对照组实际参与40例,完成30例,脱失10例(25.00%)；合计67例完成研究,平均年龄(40.7±7.5)岁。两组均未出现因为不良反应而退出研究的病例。对照组的脱失率明显高于试验组(χ2=4.5006,P=0.03),试验组的自我感觉有效率明显高于对照组。两组在调理前的亚健康评分之间,差异无统计学意义(t=0.4553,P=0.65),但是调理后,试验组的评分明显低于对照组(t=2.9564,P=0.00)。试验组的舒张压、总胆固醇和尿酸水平出现显著性下降,尤其是试验组调理前后尿酸的平均水平下降达(66.69±111.38)μmoL/L(t=3.3870,P=0.00),而对照组观察前后无明显变化。结论 氢气对高尿酸血症有一定的治疗作用,同时可改善患者的自我感觉。 |
| 英文摘要: |
| Objective To investigate the effect of hydrogen on the hyperuricemia.Methods A randomized controlled double-blind study was adopted.The patients who had been diagnosed with hyperuricemia between October 2014 and March 2015 were divided into the experimental group and the control group.Experimental group:life style intervention with hydrogen water,600 mL per day.Control group:life style intervention with placebo water group,600 mL per day.Age,blood pressure,total cholesterol,triglyceride,high density lipoprotein cholesterol (HDL-C),low density lipoprotein cholesterol(LDL-C),fasting blood glucose,blood uric acid(UA),serum creatinine (Cr) and blood urea nitrogen(BUN) were recorded when they were enrolled and after three months of intervention.By use of the sub-optimal health status evaluation questionnaire (SHSQ-25),self-sensory evaluation was respectively completed at the baseline and within one week after the deadline of three months intervention.Results A total of 80 patients were enrolled in the study.After unblinding,the actual participation in experiment group were 40 cases,with 37 cases completed and 3 cases of drop-out(7.50%);while the control group actually involved in 40 cases,and 30 cases completed with 10 cases of drop-out(25.00%).67 patients completed the study,whose average age was (40.66±7.45) years old.No quit cases due to adverse reactions occurred in both two groups.The drop-out rate of control group was significantly higher than that of the experimental group(χ2=4.5006,P=0.03).While the effective rate in the experimental group were significantly higher than those in the control group.There was no statistic difference on sub-optimal health status between the two groups prior to conditioning(t=0.4553,P=0.65).However,the significant difference of the two groups emerged after 3 months conditioning:the score of the experimental group was significantly lower than that of the control group(t=2.9564,P=0.00).The diastolic blood pressure,total cholesterol and uric acid levels in the experimental group were significantly decreased.In the experimental group,the average level of uric acid decreased by(66.69±111.38)μmoL/L (t=3.3870,P=0.002),while the control group showed no significant change.Conclusion Hydrogen has a certain therapeutic effect on hyperuricemia and can improve their self-sensory evaluation. |
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