| 梁玉莲,李传松,蒋跃绒.冠心病患者血清转化生长因子β1与肝细胞生长因子水平变化及其临床意义[J].中国临床保健杂志,2017,20(2):149-151. |
| 冠心病患者血清转化生长因子β1与肝细胞生长因子水平变化及其临床意义 |
| Analysis of serum levels of TGF-beta 1 and HGF in patients with coronary heart disease and its clinical effect |
| 投稿时间：2017-01-12 |
| DOI：10.3969/J.issn.1672-6790.2017.02.010 |
| 中文关键词: 冠心病 转化生长因子β1 肝细胞生长因子 |
| 英文关键词: Coronary disease Transforming growth factor beta1 Hepatocyte growth factor〖FL |
| 基金项目:国家自然科学青年基金[30901949(H2902)] |
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| 中文摘要: |
| 目的 探讨冠心病患者血清转化生长因子β1(TGF-β1)、肝细胞生长因子(HGF)水平的变化及其临床意义。方法 回顾性分析75例冠心病患者的临床资料,并分为急性心肌梗死组(AMI)和不稳定心绞痛组(UAP)。同时选取接受体检的健康成年人作为对照。观察三组血清TGF-β1、HGF水平,炎症细胞因子和血脂水平的差别,同时分析冠心病患者TGF-β1、HGF水平与炎症细胞因子和血脂水平的相关性。结果 三组血清TGF-β1水平由高到低分别为对照组、UAP组和AMI组,HGF水平由高到低分别为AMI组、UAP组和对照组,差异有统计学意义；三组白细胞介素18(IL-18)、白细胞介素6(IL-6)和超敏C反应蛋白(hs-CRP)水平由高到低分别为AMI组、UAP组和对照组,差异有统计学意义；三组低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)、总胆固醇(TC)水平由高到低分别为AMI组、UAP组和对照组,HDL-C水平由高到低分别为对照组、UAP组和AMI组,差异有统计学意义；冠心病患者的TGF-β1水平与IL-18、IL-6、hs-CRP、TG、TC、LDL-C水平负相关,与HDL-C水平正相关；HGF水平与IL-18、IL-6、hs-CRP、TG、TC、LDL-C水平正相关,与HDL-C水平负相关。结论 冠心病患者的TGF-β1水平较低,HGF水平较高,且与患者血清炎症细胞因子和血脂水平密切相关。 |
| 英文摘要: |
| Objective To investigate the changes of serum TGF- beta 1 and HGF levels in patients with coronary heart disease and their clinical significance.Methods The clinical data of patients with coronary heart disease recorded were retrospectively analyzed and were divided into acute myocardial infarction group (AMI) and unstable angina group (UAP).the health adults in our hospital were also enrolled as the control group.The differences of serum levels of TGF-β1,HGF,HGF,inflammatory cytokines and serum lipids were assessed in three groups,the correlation between serum TGF-β1 levels and inflammatory cytokines and serum lipid levels in patients with coronary heart disease and coronary heart disease was analyzed.Results The serum levels rank of TGF-β1 from the highest to the lowes among the three groups were control group,UAP group and AMI group.The levels rank of HGF were AMI group,UAP group and control group,all the inter-group difference was statistically significant;The levels rank of IL-18,IL-6 and hs-CRP in the three group were AMI group,UAP group and control group,all the inter-group difference was statistically significant;The levels rank of TG,TC,LDL-C in the three group were AMI group,UAP group and control group,HDL-C levels from high to low were control group,UAP group and AMI group,the difference was statistically significant.In patients with coronary heart disease ,serum TGF-β1 levels were negatively correlated with levels of IL-18,IL-6,hs-CRP,TG,TC and LDL-C,while positive correlation was detected with the level of HDL-C.the HGF levels are positively correlated with levels of IL-18,IL-6,hs-CRP,TG,TC,LDL-C,but negatively correlated with HDL-C levels.Conclusion The level of TGF-beta 1 in patients with coronary heart disease is low while the level of HGF is higher,and both are closely related to the serum levels of of inflammatory cytokines and blood lipids. |
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