| 魏晓娟,常荣,李卫,苏晓灵,刘彦民,吴金春,白玉婷,李文强.丹参多酚酸盐联合地尔硫卓治疗不稳定型心绞痛的疗效及对血清基质蛋白酶-9和髓过氧化物酶水平的影响[J].中国临床保健杂志,2018,21(4):442-445. |
| 丹参多酚酸盐联合地尔硫卓治疗不稳定型心绞痛的疗效及对血清基质蛋白酶-9和髓过氧化物酶水平的影响 |
| Efficacy and effects on serum MMP-9 and MPO levels of salvianolate combined with diltiazem for patients with unstable angina pectoris |
| 投稿时间：2017-06-10 |
| DOI：10.3969/J.issn.1672-6790.2018.04.003 |
| 中文关键词: 心绞痛,不稳定型 地尔硫卓 基质金属蛋白酶9 过氧化物酶 丹参多酚酸盐 |
| 英文关键词: Angina,unstable Diltiazem Matrix metalloproteinase 9 Peroxidase Salvianolate 〖FL |
| 基金项目:青海省科技计划项目(2014-ZJ-741) |
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| 中文摘要: |
| 目的 探讨丹参多酚酸盐联合地尔硫卓治疗不稳定型心绞痛(UAP)疗效及对患者金属基质蛋白酶-9(MMP-9)和髓过氧化物酶(MPO)的影响。方法 选取112例符合纳入标准的UAP患者作为研究对象,按随机数字表法分为对照组(n=56)和观察组(n=56)。所有入选病例均给予常规药物治疗。在此基础上,对照组患者给予地尔硫卓治疗,而观察组在对照组基础上给予丹参多酚酸盐治疗。疗程结束后,比较对照组和观察组患者临床疗效、心绞痛发作频率、每次发作持续时间、MMP-9和MPO水平。并于治疗期间,观察组间不良反应发生情况。结果 观察组患者治疗总有效率明显高于对照组(94.6%比82.1%,P＜0.05)。治疗后,与对照组相比,观察组患者心绞痛发作频率减少[观察组:(2.1±1.3)次/周,对照组:(4.2±1.1)次/周],每次发作持续时间缩短[观察组:(2.0±0.7)min,对照组:(3.7±1.3)min],MMP-9及MPO水平降低[观察组:(295.2±47.6)μg/L,对照组:(326.8±52.1)μg/L;观察组:(142.4±38.1)u/L,对照组:(161.5±40.8)u/L)],组间比较,差异均有统计学意义(均P＜0.05)。治疗期间,对照组和观察组患者均未出现严重不良反应,对照组和观察组不良反应发生率分别为10.7%和16.1%,组间比较,差异无统计学意义(P＞0.05)。结论 丹参多酚酸盐联合地尔硫卓治疗UAP疗效可靠,可以明显提高临床疗效,减少心绞痛发生频率,缩短心绞痛发作持续时间,并降低机体MMP-9和MPO水平,且不良反应少。 |
| 英文摘要: |
| Objective To investigate the clinical effect of salvianolate in combination with diltiazem in the treatment of patients with unstable angina pectoris(UAP) and its effects on matrix metalloproteinase 9 (MMP-9) and myeloperoxidase (MPO).Methods 112 patients with UAP meeting the inclusion criteria who were admitted by our hospital from June 2014 to June 2015 were selected as research objects.According to the random number table,those patients were divided into the control group(n=56) and the observation group (n=56).Besides conventional drug treatments,the control group was given diltiazem,while the observation group was given salvianolate in combination with diltiazem.Then,the curative efficacy,frequency,the duration of angina pectoris,the levels of MMP-9,MPO,and observed incidences of adverse reactions were compared between groups.Results The observation group had a therapeutic efficiency ratio of 94.6%,which was significantly higher than that of 82.1% in the control group (P<0.05).Compared with the control group,seizure frequency of the observation group was statistically reduced [(2.1±1.3) vs (4.2±1.1) times/week) and the duration of UAP was statistically shorter [(2.0±0.7) vs (3.7±1.3) min)] after the treatment (both P<0.05),and levels of MMP-9 and MPO of the observation group were statistically lower [(295.2±47.6) vs (326.8±52.1) μg/L,(142.4±38.1) vs (161.5±40.8) μg /L)].The differences were both statistically significant(P<0.05) in comparison between groups.During the treatments,there was no case of severe adverse reactions in both groups,and the incidencs of adverse reaction of the two groups were 10.7% and 16.1% respectively with no statistical difference (P>0.05).Conclusion Combined treatment of salvianolate with diltiazem for UAP is effective,which can significantly increase the curative efficiency,reduce seizure frequency,shorten the duration of angina pectoris and decrease the levels of MMP-9 and MPO with minor adverse reactions. |
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