| 沈琪琦,张之龄,吴洪,徐兵,朱健.丁苯酞联合脑苷肌肽治疗急性脑梗死患者的效果及对血清肿瘤坏死因子、白细胞介素6和血管内皮生长因子的影响[J].中国临床保健杂志,2019,22(1):28-31. |
| 丁苯酞联合脑苷肌肽治疗急性脑梗死患者的效果及对血清肿瘤坏死因子、白细胞介素6和血管内皮生长因子的影响 |
| The effect of butylphthalide combined with cattle encephalon glycoside and ignotin on acute cerebral infarction and the influence on serum TNF-α,IL-6 and VEGF levels |
| 投稿时间：2018-07-02 |
| DOI：10.3969/J.issn.1672-6790.2019.01.009 |
| 中文关键词: 脑梗死 肿瘤坏死因子α 白细胞介素6 血管内皮生长因子类 |
| 英文关键词: Brain infarction Tumor necrosis factor-alpha Interleukin-6 Vascular endothelial growth factors 〖FL |
| 基金项目:上海交通大学医工交叉项目局级课题(YG2017MS07) |
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| 中文摘要: |
| 目的 探讨丁苯酞联合脑苷肌肽对急性脑梗死患者的效果,及对血清肿瘤坏死因子(TNF)-α、白细胞介素(IL)-6和血管内皮生长因子(VEGF)水平的影响。方法 将90例急性脑梗死患者按随机数字表法分为对照组45例(给予丁苯酞治疗),观察组45例(给予丁苯酞联合脑苷肌肽治疗),共14 d。两组基础用药相同。比较两组患者治疗前、后神经功能缺损程度(NIHSS)及日常生活活动量(ADL)评分,检测两组治疗前后血清TNF-α、IL-6和VEGF水平。结果 观察组疗效显著优于对照组,差异有统计学意义(P＜0.05)。治疗后,两组NIHSS评分均低于治疗前,且观察组低于对照组,差异均有统计学意义(均P＜0.05)。治疗后,两组ADL评分高于治疗前,且观察组高于对照组,差异均有统计学意义(均P＜0.05)。治疗后,观察组血清TNF-α、IL-6水平显著低于对照组,VEGF水平显著高于对照组,差异有统计学意义(P＜0.05)。结论 丁苯酞联合脑苷肌肽能更好地改善急性脑梗死患者的神经功能,提高日常生活能力；显著降低血清TNF-α、IL-6水平,提高VEGF水平。 |
| 英文摘要: |
| Objective To explore the effect of butylphthalide combined with cattle encephalon glycoside and ignotin on the levels of serum TNF-α,IL-6 and VEGF and the therapeutic effect in acute cerebral infarction patients (ACI).Methods 90 cases with ACI were randomly divided into two groups.45 cases in the control group were treated with butylphthalide therapy.45 cases in the observation group were treated with butylphthalide combined with cattle encephalon glycoside and ignotin therapy for 14 days.The conventional treatments in two groups were same.The neurological impairment score(NIHSS) and activity of daily living(ADL) scale were evaluated and compared before and after treatment between the two groups.Enzyme linked immunosorbent assay (ELISA) was used to detect and compare the levels of TNF-α,IL-6,VEGF at the admission day,14th day after admission.Results The effective rate in observation group was significantly higher than that in control group (P<0.05).NIHSS neurological deficit score after treatment in two groups was significantly lower than that in pre-treatment,and it in observation group was significantly lower than that in control group (P<0.05).Activity of daily living (ADL) score after treatment in two groups were significantly higher than those in pre-treatment,and they in observation group were significantly higher than those in control group (P<0.05).After treatment,serum TNF-α,IL-6 levels in observation group was significantly lower than those in control group,and serum VEGF level in observation group were significantly higher than that in control group (P<0.05).Conclusion Butylphthalide combined with cattle encephalon glycoside and ignotin can promote the improvement of activities of daily living and recovery of neurological function and decrease the serum levels of TNF-α and IL-6 and raise the level of VEGF. |
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