| 莫巍,叶圣荣.前列地尔联合常规治疗对2型糖尿病周围神经病变患者的临床疗效[J].中国临床保健杂志,2019,22(1):111-114. |
| 前列地尔联合常规治疗对2型糖尿病周围神经病变患者的临床疗效 |
| Clinical observation of alprostadil combined with routine treatment in type 2 diabetic patients with peripheral neuropathy |
| 投稿时间：2018-11-09 |
| DOI：10.3969/J.issn.1672-6790.2019.01.030 |
| 中文关键词: 糖尿病神经病变 神经传导 半胱氨酸 前列地尔 |
| 英文关键词: Diabetic neuropathies Neural conduction Cysteine Alprostadil 〖FL |
| 基金项目:浙江省钱江人才计划项目(2013R10026) |
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| 中文摘要: |
| 目的 观察前列地尔联合常规治疗对2型糖尿病周围神经病变患者的临床疗效,并探讨其对患者血清同型半胱氨酸(Hcy)及抗氧化能力的影响。 方法 以入院病例号为编号,根据随机数字表,将120例2型糖尿病周围神经病变患者随机分成两组,每组60例。对照组按照常规治疗方法,观察组同时静脉滴注前列地尔。30 d后,观察临床疗效,对比治疗前后正中神经与腓总神经的运动神经传导速度(MNCV) 和感觉神经传导速度(SNCV)、多伦多临床神经病变评分(TCSS)、Hcy及总抗氧化能力(T-AOC),并记录不良反应。 结果 观察组总有效率为85.0%(51/60),高于对照组为71.7%(43/60),P<0.05；治疗后,观察组正中神经和腓总神经的SNCV分别为(49.9±1.6)m/s和(40.8±2.6)m/s,正中神经和腓总神经的MNCV分别为(45.5±3.4)m/s和(40.3±2.4)m/s,高于治疗前水平和对照组相关指标水平(P<0.05)；观察组TCSS评分(7.8±0.7)分,低于对照组(11.4±0.5)分(P＜0.05)；两组多伦多保肢评分(TESS)差异无统计学意义(P＞0.05)；治疗后,两组Hcy水平均降低,观察组Hcy(13.9±1.8)μmol/L,低于对照组(P＜0.05)；两组SOD和T-AOC水平升高,观察组分别为(86.8±2.8)nu/mL和(14.5±2.4)u/mL,高于对照组(P＜0.05)。 结论 前列地尔联合常规可有效改善2型糖尿病患者周围神经病变程度,改善运动和感觉神经传导速度,提高TCSS 评分,可能与降低患者Hcy和提高机体抗氧化能力有关。 |
| 英文摘要: |
| Objective To observe the clinical efficacy of alprostadil combined with routine therapy in type 2 diabetic patients with peripheral neuropathy,and to explore its effect on serum homocysteine(Hcy) and antioxidant capacity. Methods According to the random number table,120 patients with type 2 diabetic peripheral neuropathy were randomly divided into two groups with 60 cases in each group.The patients of the control group were given conventional treatment,while the patients of the observation group were given alprostadil intravenously.30 days later,the clinical efficacy was observed.The motor nerve conduction velocity(MNCV) and sensory nerve conduction velocity(SNCV),TCSS score,serum Hcy and antioxidant capacity of median nerve and common peroneal nerve were compared before and after treatment.The adverse reactions were recorded. Results The total effective rate of observation group was 85.0% (51/60),higher than that of control group 71.7% (43/60),P<0.05.After treatment,the SNCV of median nerve and common peroneal nerve in observation group were (49.9±1.6) m/s and (40.8±2.6) m/s respectively,and the SNCV of median nerve and common peroneal nerve were (45.5±3.4) m/s and (40.3±2.4) m/s respectively,higher than those before treatment and those of control group,P<0.05.The TCSS score of the observation group was (7.8±0.7),lower than that of the control group (11.4±0.5),P<0.05.There was no significant difference in TESS score between the two groups (P>0.05).After treatment,the levels of serum Hcy in both groups were lower than before treatment,the levels of serum Hcy was (13.9±1.8) μmol/L in the observation group ,lower than that in the control group (P<0.05).The levels of serum SOD and T-AOC in the two groups were higher than before treatment,those in the observation group was (86.8±2.8) nu/mL and (14.5±2.4) u/mL respectively,higher than those of the control group,P<0.05. Conclusion Alprostadil combined with routine therapy can effectively improve the degree of peripheral neuropathy,motor and sensory nerve conduction velocity and TCSS score in patients with type 2 diabetes mellitus,which may be related to the decrease of Hcy and the increase of antioxidant capacity. |
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