| 程庆砾.老年患者多重用药与肾功能不全[J].中国临床保健杂志,2020,23(1):23-26. |
| 老年患者多重用药与肾功能不全 |
| Polypharmacy and renal insufficiency in the elderly patients |
| 投稿时间：2019-12-16 |
| DOI：10.3969/J.issn.1672-6790.2020.01.006 |
| 中文关键词: 慢性病共病 肾功能不全 处方不当 老年人 |
| 英文关键词: Multiple chronic conditions Renal Insufficiency Inappropriate prescribing Aged |
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| 中文摘要: |
| 临床上老年共病患者的多重用药常会引发药物不良反应,容易导致肾损伤。其主要原因有多器官老化对药物代谢的影响、增龄改变导致肾储备功能降低、老年肾功能评估不够准确、对老年共病治疗缺乏统一管理以及临床医师对多重用药的危害认识不足。预防多重用药对老年患者的肾损伤应注意在用药前精确评估肾功能,用药过程中要注意用药个体化和密切监测药物的不良反应,必要时应与临床药师讨论精简患者的处方,尽最大可能保护老年患者的肾功能。 |
| 英文摘要: |
| Polypharmacy in the elderly patients with comorbidity often causes adverse drug reactions and leads to kidney injury easily.The main reasons are the effects of multiple organ aging on drug metabolism,the decrease of renal reserve function in the aged,the inaccurate evaluation of renal function in the elderly,the lack of unified management of the treatment of comorbidity and the insufficient understanding of the harm of polypharmacy by clinicians.To prevent kidney damage caused by polypharmacy,it is necessary to accurately assess the renal function of the elderly patients before medication,individualization of medications and monitor closely the adverse drug sreactions during the treatments.If necessary,it should be discussed with clinical pharmacists to target deprescribing to protect the renal function of the elderly patients as much as possible. |
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