| 张媛媛,刘怀珍,李居一,牛知影,张进军.2型糖尿病患者尿白蛋白/肌酐比与血清胆红素的相关研究[J].中国临床保健杂志,2020,23(3):400-402. |
| 2型糖尿病患者尿白蛋白/肌酐比与血清胆红素的相关研究 |
| Correlational studies on urinary albumin/creatinine ratio and serum bilirubin in type 2 diabetic patients |
| 投稿时间：2018-01-06 |
| DOI：10.3969/J.issn.1672-6790.2020.03.028 |
| 中文关键词: 糖尿病,2型 糖尿病肾病 胆红素 白蛋白尿 |
| 英文关键词: Diabetes mellitus,type 2 Diabetic nephropathies Bilirubin Albuminuria 〖FL |
| 基金项目:安徽省卫生计生委中医药科研基金项目(2016ZY12) |
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| 中文摘要: |
| 目的 探讨2型糖尿病(T2DM)患者尿白蛋白/肌酐比(UACR)与血清总胆红素(TBIL)、直接及间接胆红素(DBIL、IBIL)之间的关联性。方法 选择517例住院治疗的T2DM患者,根据UACR分成三组,正常白蛋白尿组(A组)274例,微量白蛋白尿组(B组)167例,大量白蛋白尿组(C组)76例,采用非参数检验法比较三组间血清TBIL、DBIL、IBIL的差异,同时行相关因素分析。结果 B组、C组分别与A组相比,TBIL、DBIL、IBIL水平明显下降；C组与B组相比,TBIL、DBIL 水平明显下降,均P<0.05。在UACR>30 mg/g人群中,UACR的相关分析表明:UACR与病程、收缩压(SBP)、平均动脉压(MAP)、血肌酐(CR)、总胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)呈正相关；UACR与TBIL、DBIL 、IBIL呈负相关,均P<0.05。结论 血清胆红素可能是T2DM患者白蛋白尿的保护因素。 |
| 英文摘要: |
| Objective To investigate the correlation urinary albumin/creatinine ratio (UACR),serum total bilirubin (TBIL),direct and indirect bilirubin (DBIL,IBIL) in patients with type 2 diabetes mellitus (T2DM). Methods 517 patients with T2DM were enrolled.On the basis of UACR,all patients were divided into three groups:274 cases of normalalbuminuria group (group A),167cases of microalbuminuria group (group B),76cases of macroalbuminuria group (group C).The differences of TBIL,DBIL and IBIL in three groups were compared.Non-parametric test was used to analysize.The correlation factors analysis of UACR was performed. Results The levels of serum TBIL,DBIL and IBIL were significantly decreased in group B and group C,respectively,compared with group A.Compared with group B,serum TBIL and DBIL were significantly decreased in group C,all P<0.05.In the UACR>30 mg/g population,correlation analysis showed that UACR was positively correlated with the course of diabetes,systolic blood pressure (SBP),average arterial pressure (MAP),serum creatinine (CR),total cholesterol (TC),high density lipoprotein (HDL),low density lipoprotein (LDL)；UACR was negatively correlated with serum TBIL,DBIL,IBIL,all P<0.05. Conclusion Serum bilirubin maybe a pretective factor for albuminuria in T2DM patients. |
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