| 孙雪林,康薇,田晓鑫,胡欣,刘德军.人类白细胞抗原相关的药物超敏反应[J].中国临床保健杂志,2020,23(3):423-428. |
| 人类白细胞抗原相关的药物超敏反应 |
| Overview of HLA-associated adverse drug reactions |
| 投稿时间：2020-03-07 |
| DOI：10.3969/J.issn.1672-6790.2020.03.034 |
| 中文关键词: 人类白细胞抗原 药物过敏 药物相关性副作用和不良反应 遗传药理学 |
| 英文关键词: HLA Drug hypersensitivity Drug-related side effects and adverse reactions Pharmacogenetics 〖FL |
| 基金项目:中央保健重点专项课题(W2016ZD01) |
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| 中文摘要: |
| 药物不良反应(ADR)是临床治疗过程中导致死亡率升高的重要原因之一,也是药物撤市的主要原因。除了与药物药理活性有关的经典不良反应外,有些ADR是不可预测的,与药物剂量无关,并且容易发生在某些具有遗传易感的个体中。此类ADR大部分是免疫驱动的,称为超敏反应。越来越多的研究表明,特定的人类白细胞抗原(HLA)等位基因会增加药物超敏反应的风险。目前具有药理遗传学证据的药物超敏反应包括阿巴卡韦超敏综合征,以及别嘌呤醇和卡马西平引起的严重皮肤不良反应。 |
| 英文摘要: |
| Adverse drug reactions is one of the most important causes of morbidity and mortality and constitute the leading reason of drug withdrawal from the market.Besides classical reactions that are related to pharmacologic activity of the drug,some reactions are unpredictable,not dose dependent,and seem to occur in genetically predisposed individuals.The majority of this reaction is immunologically driven and they are referred to as hypersensitivity reactions.A growing number of studies provided evidences that specific HLA alleles increase the risk of developing hypersensitivity drug reactions.In this context,drug hypersensitivities that have more robust pharmacogenetic data include abacavir hypersensitivity syndrome and severe cutaneous adverse reactions induced by allopurinol and carbamazepine. |
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