| 兰晓阳,张芳芳,徐瑞,李婉君,冉晔,侯磊,田成林,张兴文,于生元.新型冠状病毒感染对缺血性卒中影响的单中心小样本研究[J].中国临床保健杂志,2023,26(2):158-161. |
| 新型冠状病毒感染对缺血性卒中影响的单中心小样本研究 |
| The effect of COVID-19 infection on ischemic cerebrovascular disease:a single center small sample study |
| 投稿时间：2023-02-01 |
| DOI：10.3969/J.issn.1672-6790.2023.02.004 |
| 中文关键词: 缺血性卒中 新型冠状病毒感染 炎症 血液凝固 危险因素 |
| 英文关键词: Ischemic stroke COVID-19 Inflammation Blood coagulation Risk factors 〖FL |
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| 中文摘要: |
| 目的 探讨新型冠状病毒感染对缺血性卒中的影响。方法 连续收集2022年12月12日至2023年1月12日中国人民解放军总医院第一医学中心神经内科病房收住的急性缺血性卒中患者的病历资料。研究项目包括基线资料(年龄、性别),危险因素(高血压、糖尿病、冠心病/心肌梗死、高脂血症、脑血管病史、吸烟史、饮酒史、家族史),脑梗死的TOAST分型,起病时的炎症指标、凝血指标,与既往我国急性缺血性卒中数据进行比较差异。结果 合并新型冠状病毒感染组患者的糖尿病比例显著增高。近半数的患者白细胞介素-6、C反应蛋白、D-二聚体、血浆纤维蛋白原异常。病因分型方面,大动脉粥样硬化型及小动脉闭塞型患者比例较我国既往流调数据增多。心源性栓塞的发生比例并未见增多。结论 新型冠状病毒感染伴发急性缺血性卒中并不常见,其更容易发生于存在常见危险因素的患者人群中,尤其是合并糖尿病的患者中。新型冠状病毒感染伴发急性缺血性卒中患者的炎症指标异常增高。 |
| 英文摘要: |
| Objective To explore the effect of novel coronavirus infection on ischemic cerebrovascular disease.Methods The data of patients with acute ischemic cerebral infarction in the Department of Neurology of the First Medical Center of Chinese PLA General Hospital from December 12,2022 to January 12,2023 were collected continuously.The research items included baseline data (age,gender),risk factors (hypertension,diabetes,coronary heart disease/myocardial infarction,hyperlipidemia,cerebrovascular disease history,smoking history,drinking history,family history),TOAST classification of cerebral infarction,and coagulation indicators at the onset of the disease.Compared with the previous acute ischemic cerebrovascular disease in China.Results The proportion of diabetes in patients with COVID-19 was higher.Nearly half of the patients had abnormalities in interleukin-6,C-reaction protein,D-dimer and plasma fibrinogen.In terms of etiology classification,the proportion of patients with large atherosclerotic type and small artery occlusive type increased significantly compared with the previous epidemiological data in China.The incidence of cardiogenic embolism did not increase significantly.Conclusions COVID-19 with acute ischemic stroke is not common,and COVID-19 is more likely to occur in patients with classic risk factors,especially in patients with diabetes.Inflammatory markers in COVID-19 patients with acute ischemic stroke are abnormally high. |
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