| 赵哲,刘霖,赵力博,苏小凤,王欢欢,何子君,房凤凤,李开亮,范利.老年男性阻塞性睡眠呼吸暂停患者合并代谢综合征相关不良心血管事件的预后[J].中国临床保健杂志,2023,26(2):184-188. |
| 老年男性阻塞性睡眠呼吸暂停患者合并代谢综合征相关不良心血管事件的预后 |
| Prognosis of adverse cardiovascular events associated with combined metabolic syndrome in elderly male patients with obstructive sleep apnea |
| 投稿时间：2022-07-08 |
| DOI：10.3969/J.issn.1672-6790.2023.02.010 |
| 中文关键词: 睡眠呼吸暂停,阻塞性 代谢综合征 心血管疾病 预后 老年人 |
| 英文关键词: Sleep apnea,obstructive Metabolic syndrome Cardiovascular diseases Prognosis Aged 〖FL |
| 基金项目:军队装备建设应用研究项目(LB20211A010013)；军队保健专项科研课题(19BJZ34,22BJZ52) |
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| 中文摘要: |
| 目的 明确老年男性阻塞性睡眠呼吸暂停(OSA)合并代谢综合征(MetS)患者相关主要不良心血管事件(MACE)的预后。方法 选取2015年1月至2017年10月在北京及甘肃6家医院睡眠中心收集确诊为OSA的老年男性患者704例,根据有无MetS,分为MetS组(392例)和非MetS组(312例)。比较2组患者的基线特征、多导睡眠监测数据及相关病史,采用Cox回归分析研究老年男性OSA患者合并MetS相关MACE的预后情况。结果 在704例患者中,392例(55.68%)老年男性OSA患者合并MetS,在随访期间,68例(9.6%)患者发生了MACE,其中47例合并MetS。多因素分析显示,MetS与MACE的发生有关,调整后的风险比(aHR)为2.09,95%CI:1.19~3.68,P=0.011。亚组分析表明,年龄＜70岁(aHR=2.53,95%CI:1.18~5.40,P=0.017)、重度OSA(aHR=2.39,95%CI:1.03~5.55,P=0.043)、超重(aHR=4.03,95%CI:1.63~9.94,P=0.002)的患者,其合并MetS时患MACE的风险更高。结论 老年男性OSA患者合并MetS患病率较高,MetS是影响老年男性OSA患者MACE预后的相关因素。年龄＜70岁、超重以及重度OSA合并MetS的男性患者发生MACE的风险显著升高。 |
| 英文摘要: |
| Objective To clarify the prognosis of major adverse cardiovascular events (MACE) associated with obstructive sleep apnea (OSA) in elderly men with combined metabolic syndrome (MetS).Methods From January 2015 to October 2017,704 elderly male patients diagnosed with OSA were collected from sleep centers of six hospitals in Beijing and Gansu and divided into MetS (392 patients) and non-MetS groups (312 patients).Baseline characteristics,polysomnography data and relevant medical history of patients in both groups were counted,and Cox survival analysis was used to discover the prognosis of elderly male OSA patients with combined MetS-related MACE.Results Three hundred and ninety-two (55.68%) older men with OSA had combined MetS,and 68 (9.6%) experienced MACE during follow-up,47 of whom had combined MetS.In 704 patients,multivariate analysis showed that MetS was associated with the development of MACE,adjusted hazard ratio (aHR):2.09,95%CI:1.19-3.68,P=0.011.Subgroup analysis showed that patients aged<70 years (aHR:2.53,95%CI:1.18-5.40,P=0.017),with severe OSA (aHR:2.39,95%CI:1.03-5.55,P=0.043),overweight (aHR:4.03,95%CI:1.63-9.94,P=0.002) had a higher risk of developing MACE when combined with MetS.Conclusions Elderly men with OSA have a higher prevalence of comorbid MetS,which is a relevant factor affecting the prognosis of MACE in older men with OSA.The risk of MACE is significantly higher for male patients aged<70 years,overweight,and those with severe OSA combined with MetS. |
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