| 任梦玉,周婉,范文华,叶山东.2型糖尿病患者合并肾脏病的相关危险因素分析[J].中国临床保健杂志,2023,26(2):233-236. |
| 2型糖尿病患者合并肾脏病的相关危险因素分析 |
| The related risk factors analysis of type 2 diabetics complicated with diabetic kidney disease |
| 投稿时间：2023-01-10 |
| DOI：10.3969/J.issn.1672-6790.2023.02.021 |
| 中文关键词: 糖尿病,2型 糖尿病肾病 危险因素 保护因素 肾小球滤过率 |
| 英文关键词: Diabetes mellitus,type 2 Diabetic nephropathies Risk factors Protective factors Glomerular filtration rate 〖FL |
| 基金项目:国家自然科学基金项目(81800713)；安徽省中央引导地方科技发展专项(2017070802D147) |
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| 中文摘要: |
| 目的 对2型糖尿病(T2DM)患者糖尿病肾脏病(DKD)的危险因素进行分析。方法 回顾性分析2020年5月至2022年2月在安徽医科大学附属省立医院内分泌科住院的248例T2DM患者的临床资料,根据尿白蛋白/肌酐比(UACR)或估算肾小球滤过率(eGFR)结果,分为单纯T2DM组(T2DM组,68例)、T2DM合并DKD组(DKD组,180例),收集各组年龄、糖尿病病程、身高、体重、体重指数(BMI)、高血压病史、吸烟史、T2DM治疗方式,抽取患者清晨空腹静脉血,检测血糖、糖化血红蛋白(HbA1c)和血脂等,比较2组一般资料和实验室指标,对2组临床资料进行单因素分析,并对其中差异有统计学意义的因素进行赋值和多因素logistic回归分析。结果 (1)组间与T2DM组比较,DKD组年龄、糖尿病病程、高血压病史、吸烟史、HbA1c、高密度脂蛋白胆固醇(HDL-C)、是否使用胰岛素控制血糖存在差异,差异有统计学意义(P值均＜0.05)。(2)单因素分析结果显示,DKD发生受患者年龄、糖尿病病程、高血压病史、吸烟史、HbA1c、高密度脂蛋白胆固醇(HDL-C)、使用胰岛素控制血糖等因素影响(P值均＜0.05)。(3)多因素非条件logistic 回归分析结果显示,高龄(≥50岁)、糖尿病病程长(≥10年)、有高血压病史、吸烟史、HbA1c(≥8.5%)、尿素氮(≥7.14 mmol/L)、T2DM患者使用胰岛素控制血糖均为T2DM住院患者发生DKD的危险因素(OR＞1.00,P值均＜0.05)；HDL-C(≥1 mmol/L)则为影响T2DM患者发生DKD的保护因素(OR＜1.00,P＜0.05)。结论 HDL-C为T2DM住院患者发生DKD的保护因素；长病程、较高的HbA1c和LDL-C、高血压病史、吸烟和胰岛素治疗是DKD的危险因素。 |
| 英文摘要: |
| Objective To anlyse the risks factor of diabetic kidney disease (DKD)in patients with type 2 diabetes. Methods The 248 patients with type 2 diabetes who were hospitalized in the Endocrinology Department of Anhui Provincial Hospital from May 2020 to February 2022 were retrospectively analyzed,were divided into T2DM group (68 cases) and DKD group (180 cases).The age,duration of diabetes,height,weight,BMI,history of hypertension,smoking history,and type 2 diabetes treatment were collected in each group.Venous blood was used to detect fasting blood glucose(FBG),HbA1c and lipids etc.Univariate analysis was performed on the clinical data of the two groups and multivariate logistic regression analysis was used to screen the risk factors of DKD in patients with type 2 diabetes.Results (1)There were significant of differens in age,diabetic duration,incidence of hypertention,history of smoking,HbA1c,HDL-C and insulin use between two groups(P<0.05).(2)Univariate analysis showed that the incidence of DKD might be affected by the patient′s age,duration of diabetes,hypertension,smoking history,glycosylated hemoglobin(HbA1c),high-density lipoprotein cholesterol (HDL-C),and whether insulin treatment(P<0.05).(3)Multivariate unconditional logistic regression analysis showed that advanced age (≥50 years old),long duration of diabetes(≥10 years),history of hypertension,smoking history,HbA1c (≥8.5%) and the use of insulin were risk factors for DKD (OR>1.00,P<0.05);HDL-C (≥1 mmol/L) was the protective factors of DKD(OR＜1.00,P＜0.05)。Conclusions HDL-C (greater than 1 mmol/L) is a protective factor for DKD,long duration (≥10 years),higher HbA1c and LDL-C,a history of hypertension,a history of smoking and the use of insulin are risk factors for DKD in hospitalized patients with type 2 diabetes. |
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