| 张桂兰,王晶,陈婷,刘芳,郑一瑾,彭李明,李默,汤继臣,程叶坪.均态膳联合个体化运动干预对FTO/UCP2不同基因型肥胖人群心血管风险因素的影响[J].中国临床保健杂志,2023,26(3):337-341. |
| 均态膳联合个体化运动干预对FTO/UCP2不同基因型肥胖人群心血管风险因素的影响 |
| A study on the effects of homogeneous diet combined with individualized exercise intervention on cardiovascular risk factors in obese individuals with different genotypes of FTO/UCP2 |
| 投稿时间：2023-02-27 |
| DOI：10.3969/J.issn.1672-6790.2023.03.011 |
| 中文关键词: 肥胖症 心血管疾病 精准医学 膳食,健康 运动疗法 |
| 英文关键词: Obesity Cardiovascular diseases Precision medicine Diet,healthy Exercise therapy 〖FL |
| 基金项目:湖北省卫生健康科研基金资助项目(WJ2019H243) |
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| 中文摘要: |
| 目的 探究均态膳联合个体化运动干预对FTO/UCP2不同基因型肥胖人群心血管风险因素的影响。方法 选取2018年1月至2021年1月于武汉科技大学附属孝感医院接受体检的健康人群,筛选符合条件的300例受试者作为研究对象,将所有受试者分为3组(均态膳联合个体化运动干预组、个体化运动干预组和对照组),每组100例。并根据每组受试者FTOrs9939609和UCP2rs660339基因位点突变检测结果将其分为4个亚组:携带单一FTO、携带单一UCP2、携带FTO和UCP2以及未携带FTO/UCP2,每个亚组25例。比较各组干预前后血压[舒张压(DBP)、收缩压(SBP)]、心肺耐力[梅脱值(MET)]、心肌耗氧量[SBP与心率(HR)乘积]等心血管风险因素变化情况。结果 干预前后均态膳联合个体化运动干预组、个体化运动干预组和对照组DBP和SBP变化的差异无统计学意义(P>0.05)。在干预组和对照组内,和携带FTO/UCP2风险基因者相比,未携带FTO/UCP2者DBP和SBP均较低,差异有统计学意义(P<0.05)。干预前后,均态膳联合个体化运动干预组受试者MET高于对照组和个体化运动干预组,HR和心肌耗氧量均低于对照组和个体化运动干预组,同时携带FTO和UCP2受试者MET较低、心肌耗氧量均较高,而未携带FTO/UCP2受试者HR均较低,差异有统计学意义(P<0.05)。结论 均态膳联合个体化运动干预能够改善心血管代谢,同时,携带FTO/UCP2基因的肥胖人群在均态膳联合个体化运动干预中的心血管代谢健康收益减少。 |
| 英文摘要: |
| Objective To explore the effects of balanced diet and individualized exercise intervention on cardiovascular risk factors in obese people with different genotypes of FTO/UCP2. Methods According to the inclusion and exclusion criteria,a total of 300 eligible subjects who received physical examination in our hospital from January 2018 to January 2021 were selected as research objects.all subjects were divided into three groups (balanced diet and individualized exercise intervention group,individualized exercise intervention group and control group),with 100 cases in each group.According to the results of FTOrs9939609 and UCP2rs660339 gene mutation detection,subjects in each group were divided into four subgroups:single FTO carrier,single UCP2 carrier,FTO and UCP2 carrier and no FTO/UCP2 carrier,with 25 cases in each subgroup.The changes of cardiovascular risk factors such as blood pressure[diastolic blood pressure (DBP),systolic blood pressure (SBP)],cardiopulmonary endurance[Metate value (MET)],myocardial oxygen consumption[product of SBP and heart rate (HR)]were statistically analyzed after the intervention.Results After intervention,there were no significant difference in DBP and SBP among all groups (P>0.05),while the DBP and SBP of subjects without FTO/UCP2 were lower among all subgroups,and the differences were significant (P<0.05).After the intervention,MET of subjects in the balanced diet and individualized exercise intervention group was higher than that in the control group and individualized exercise intervention group,and HR and myocardial oxygen consumption were lower than those in the control group and individualized exercise intervention group.Meanwhile,subjects with FTO and UCP2 had lower MET and higher myocardial oxygen consumption among all subgroups,while subjects without FTO/UCP2 had lower HR.The difference was significant (P<0.05).Conclusions Balanced diet and individualized exercise intervention can effectively reduce the risk of cardiovascular disease.Meanwhile,obese people carrying FTO/UCP2 genes may increase the risk of cardiovascular disease. |
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