| 李术环,李宏彬.全段甲状旁腺激素水平在预测老年血液透析患者心脑血管事件中的作用[J].中国临床保健杂志,2023,26(3):380-383. |
| 全段甲状旁腺激素水平在预测老年血液透析患者心脑血管事件中的作用 |
| The role of iPTH levels in predicting cardiovascular and cerebrovascular events in elderly hemodialysis patients |
| 投稿时间：2023-02-19 |
| DOI：10.3969/J.issn.1672-6790.2023.03.021 |
| 中文关键词: 肾透析 甲状旁腺素 血管疾病 危险因素 老年人 |
| 英文关键词: Renal dialysis Parathyroid hormone Vascular diseases Risk factors Aged 〖FL |
| 基金项目:北京市东城区卫生科技计划项目(东卫健研2021-12) |
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| 中文摘要: |
| 目的 探讨血清全段甲状旁腺激素(iPTH)水平在老年血液透析心脑血管事件预测中的作用及价值。方法 回顾性分析2019年4月至2022年1月老年血液透析患者79例为研究对象,入院后次日早晨采集外周空腹血,采用化学发光法检测血清iPTH水平,并根据测定结果分为低水平组(<150 ng/L)、中水平组(150~300 ng/L)和高水平组(>300 ng/L),3组均连续完成6个月血液透析治疗,治疗完毕后统计心脑血管事件的发生,比较3组心脑血管事件发生率；对老年血液透析患者心脑血管事件发生率进行单因素和多因素logistic回归分析。结果 中水平组急性心肌梗死、心绞痛、脑梗死、脑出血、心力衰竭、短暂性脑缺血发作发生率低于低水平组及高水平组(P<0.05)；79例老年血液透析患者中27例发生心脑血管事件,发生率为34.18%；单因素及多因素logistic回归分析结果表明:年龄、糖尿病、iPTH水平、超敏C反应蛋白水平是老年血液透析患者心脑血管事件发生独立危险因素(P<0.05)。结论 iPTH水平能预测老年血液透析患者心脑血管事件发生率,其表达水平过高或过低均能增加心脑血管事件发生率,且受到影响因素较多,应根据可能危险因素进行预防干预。 |
| 英文摘要: |
| Objective To investigate the role and value of serum total parathyroid hormone (iPTH) level in predicting cardiovascular and cerebrovascular events in elderly hemodialysis patients.Methods Seventy-nine elderly hemodialysis patients from April 2019 to January 2022 were selected retrospectively.Serum iPTH levels were measured by chemiluminescence method,and were divided into low level group (<150 ng/L),medium level group (150-300 ng/L),and high level group (>300 ng/L) according to the measurement results.The three groups all completed hemodialysis treatment for six consecutive months.After the treatment,the incidence of cardiovascular and cerebrovascular events was calculated and compared;The incidence of cardiovascular and cerebrovascular events in elderly hemodialysis patients was analyzed by single factor and multi factor logistic regression.Results The incidence of acute myocardial infarction,angina pectoris,cerebral infarction,cerebral hemorrhage,heart failure and transient ischemic attack in the medium level group was lower than that in the low level group and the high level group (P<0.05).In the follow-up of 79 elderly hemodialysis patients,27 patients had cardiovascular and cerebrovascular events,the incidence rate was 34.18%.The results of univariate and multivariate logistic regression analysis showed that age,diabetes,iPTH level and hs CRP level were independent risk factors for cardiovascular and cerebrovascular events in elderly hemodialysis patients (P<0.05).Conclusions The level of iPTH can predict the incidence of cardiovascular and cerebrovascular events in elderly hemodialysis patients,and too high or too low of iPTH all can increase the incidence of cardiovascular and cerebrovascular events,and it is affected by many factors,so preventive intervention should be carried out according to possible risk factors. |
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