| 耿彪,孙珍贵,汪丽静,陈兴无.血小板和淋巴细胞比值对程序性细胞死亡蛋白-1抑制剂联合化疗治疗非小细胞肺癌患者的价值[J].中国临床保健杂志,2023,26(4):531-534. |
| 血小板和淋巴细胞比值对程序性细胞死亡蛋白-1抑制剂联合化疗治疗非小细胞肺癌患者的价值 |
| Relationship between platelet/lymphocyte ratio and efficacy of PD-1 inhibitor combined with chemotherapy in patients with non-small cell lung cancer |
| 投稿时间：2023-04-05 |
| DOI：10.3969/J.issn.1672-6790.2023.04.022 |
| 中文关键词: 癌,非小细胞肺 血小板 淋巴细胞 程序性细胞死亡受体1 预后 |
| 英文关键词: Carcinoma,non-small-cell lung Blood Platelets Lymphocytes Programmed cell death 1 receptor Prognosis 〖FL |
| 基金项目:安徽省自然科学基金项目(2008085QH351)；弋矶山医院引进人才科研项目(YR201904)；皖南医学院第一附属医院“三新”项目(Y22055) |
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| 中文摘要: |
| 目的 探讨治疗前外周血血小板和淋巴细胞比值(PLR)与应用程序性细胞死亡蛋白-1(PD-1)抑制剂联合化疗治疗非小细胞肺癌患者(NSCLC)中的价值。方法 回顾性分析2020年1月至2022年1月皖南医学院第一附属医院呼吸与危重症医学科收治的90例晚期NSCLC患者病历资料。收集所有NSCLC患者治疗前血常规PLR数值,根据外周血PLR分为低PLR组(PLR<200,43例)和高PLR组(PLR≥200,47例),所有患者均接受至少6个周期的治疗。治疗后定期复查进行疗效评价,分析比较2组NSCLC患者的治疗疗效以及无进展生存期(PFS)、总生存期(OS)情况,分析PLR与治疗疗效、PFS、OS之间的关系。结果 90例患者中,治疗前低PLR组有43例,高PLR组有47例,经过6个周期治疗后,有18例患者取得完全缓解,42例患者取得部分缓解,14例患者病情达到稳定,另有16例患者发生疾病进展,客观缓解率为66.7%,疾病控制率为82.2%。统计分析显示,低PLR组经PD-1抑制剂联合化疗治疗后其客观缓解率、疾病控制率均高于高PLR组(χ2=4.595,P=0.032；χ2=9.706,P=0.002)。Kaplan-Meier分析显示,低PLR组的PFS、OS均比高PLR组延长。多因素Cox回归模型分析表明,PLR是影响患者生存率的独立危险因素(HR=1.312,P=0.035)。结论 治疗前患者高PLR值可能对PD-1抑制剂联合化疗治疗的敏感性下降,生存预后较差。 |
| 英文摘要: |
| Objective To investigate the prognostic value of pretreatment platelet-to-lymphocyte ratios (PLR) in patients with non-small cell lung cancer (NSCLC) treated with PD-1 inhibitor combined with chemotherapy.Methods The medical records of 90 patients with advanced NSCLC admitted to the Department of Respiratory and Critical Care Medicine of the First Affiliated Hospital of Wannan Medical College from January 2020 to January 2022 were retrospectively analyzed.Pre-treatment PLR values were collected from all NSCLC patients.All patients received at least 6 cycles of treatment.According to PLR,patients with NSCLC were divided into low PLR (PLR<200,43 cases) and high PLR group (PLR≥ 200,47 cases).The therapeutic effect,progression-free survival (PFS),and overall survival (OS) of the two groups of NSCLC patients were analyzed and compared,and the relationship between PLR and therapeutic effect,PFS and OS was analyzed.Results Of the 90 patients,there were 43 cases in the low PLR group and 47 cases in the high PLR group.After 6 cycles of treatment,18 patients achieved complete remission,42 patients achieved partial remission,14 patients achieved stable disease,and 16 patients developed disease progression.The objective response rate was 66.7% and the disease control rate was 82.2%.Statistical analysis showed that the objective response rate and disease control rate of the low PLR group after PD-1 inhibitor combined with chemotherapy treatment were higher than those of the high PLR group(χ2=4.595,P=0.032；χ2=9.706,P=0.002).Kaplan-Meier analysis showed that PFS and OS of the low PLR group were longer than those of the high PLR group.Multivariate Cox regression model analysis showed that PLR ratio was an independent risk factor affecting patient survival.Conclusions Pretreatment patients with high PLR may be less sensitive to PD-1 inhibitor combination chemotherapy and have poorer survival prognosis. |
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