| 李素鹏,焦真真,孙晓芳,于宝军,谭海艳.老年女性颈动脉斑块合并缺血性脑卒中的影响因素分析[J].中国临床保健杂志,2023,26(5):666-670. |
| 老年女性颈动脉斑块合并缺血性脑卒中的影响因素分析 |
| Analysis of carotid plaque with ischemic stroke in elderly women |
| 投稿时间：2023-07-22 |
| DOI：10.3969/J.issn.1672-6790.2023.05.019 |
| 中文关键词: 缺血性卒中 颈动脉狭窄 危险因素 妇女 老年人 |
| 英文关键词: Ischemic stroke Carotid stenosis Risk factors Women Aged 〖FL |
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| 中文摘要: |
| 目的 探讨老年女性颈动脉斑块合并缺血性脑卒中的影响因素。方法 选取2022年4月至2023年6月枣庄市妇幼保健院经颈动脉超声检查确诊颈动脉斑块的患者60例、斑块合并缺血性脑卒中53例及同期健康体检志愿者60例为研究对象；比较组间年龄、体重指数、慢性疾病史、实验室指标及吸烟史、饮酒史等基线资料,结合单因素与logistic 回归分析结果,建立老年女性颈动脉斑块合并缺血性脑卒中影响因素预测模型,作受试者工作特征(ROC)曲线分析模型预测价值。结果 (1)3组组间收缩压、高血压病史、冠心病、表皮生长因子受体(EGFR)、同型半胱氨酸、总胆固醇(TC)及高密度脂蛋白胆固醇(HDL-C)差异有统计学意义(P＜0.05),斑块组及斑块合并卒中组收缩压、高血压病史、冠心病、同型半胱氨酸及TC水平显著高于健康志愿者组,EGFR及HDL-C水平显著低于健康志愿者组(P＜0.05)；(2)经过logistic回归分析发现,收缩压、高血压病史、冠心病、EGFR、TC及HDL-C是颈动脉斑块发生的影响因素,差异有统计学意义(P＜0.05)；(3)经过logistic回归分析发现,收缩压、高血压病史、同型半胱氨酸及TC是颈动脉斑块合并缺血性脑卒中发生的影响因素(P＜0.05)；(4)根据筛选出的影响因素绘制ROC曲线,结果显示,预测模型最佳临界值为0.089,ROC曲线下面积为0.705(0.645~0.747)、0.711(0.656~0.775)、0.774(0.657~0.806)、0.809(0.787~0.996)。结论 收缩压、高血压病史、同型半胱氨酸及TC是临床老年女性颈动脉斑块合并缺血性脑卒中发病的影响因素。 |
| 英文摘要: |
| Objective To explore the influencing factors of carotid plaque combined with ischemic stroke in elderly women.Methods Sixty patients with clinical carotid artery ultrasound examination confirmed by carotid artery plaque,53 patients with plaque combined with ischemic stroke and 60 volunteers with healthy physical examination in the same period from April 2022 to June 2023 were included in Zaozhuang Maternity and Child Care Community Health Service Centers.Comparing baseline data on age,BMI,history of chronic diseases,laboratory indicators,smoking history and alcohol consumption history between groups,combining the results of the univariate and logistic regression analysis,establishing a model to predict the influencing factors of carotid plaque combined with ischemic stroke in elderly women,the receiver operating characteristic curve (ROC),the predictive value of the curve analysis model.Results (1) There were statistically significant differences in systolic blood pressure,hypertension history,coronary heart disease,EGFR,homocysteine,TC and HDL-C among the three groups (P<0.05),Systolic BP,hypertension history,coronary heart disease,homocysteine and TC levels were significantly higher in the plaque group and plaque with stroke group than those in the healthy volunteer group.The EGFR and HDL-C levels were significantly lower than those in the healthy volunteer group (P<0.05).(2) After logistic regression analysis,systolic blood pressure,hypertension history,coronary heart disease,EGFR,TC and HDL-C were the factors influencing the occurrence of carotid plaque (P<0.05).(3) After logistic regression analysis,systolic blood pressure,hypertension history,homocysteine and TC were the influencing factors in the occurrence of carotid plaque combined with ischemic stroke (P<0.05).(4) According to the selected influencing factors,the ROC curve was drawn and the results showed that the optimal cut-off value of the prediction model was 0.089 and the area under the ROC curve (area under curve,AUC) was 0.705(0.645-0.747),0.711(0.656-0.775),0.774(0.657-0.806) and 0.809(0.787-0.996).Conclusions Systolic blood pressure,hypertension history and TC are the influencing factors in the occurrence of carotid plaque combined with ischemic stroke in elderly women. |
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