| 张秋君,吴圣,周守兵,李文玉,张倩玉,胡丹丹,刘虎.肉瘤患者的临床特征及预后[J].中国临床保健杂志,2023,26(5):702-704. |
| 肉瘤患者的临床特征及预后 |
| Clinical features and prognosis of patients with sarcoma |
| 投稿时间：2023-06-02 |
| DOI：10.3969/J.issn.1672-6790.2023.05.028 |
| 中文关键词: 肉瘤 乳酸脱氢酶类 预后 存活率 复发 |
| 英文关键词: Sarcoma Lactate dehydrogenases Prognosis Survival rate Recurrence 〖FL |
| 基金项目:安徽省重点学科项目(2021sjlczdzk)；“科大新医学”联合基金项目(WK9110000010)；中国科学技术大学附属第一医院(安徽省立医院)院内青年基金项目(2020YJQN021,2022YJQN023) |
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| 中文摘要: |
| 目的 探讨肉瘤的临床特征、治疗方法和预后之间的关系,寻找影响预后的独立因素。方法 回顾性分析2018年9月至2021年6月中国科学技术大学附属第一医院(安徽省立医院)收治的59例肉瘤患者的临床资料及总生存期(OS),使用单因素及多因素Cox回归分析临床特征与预后的关系,Log-rank检验分析特定临床特征与OS的关系。结果 59例患者均组织学证实为肉瘤,其中5例确诊后无手术机会,54例曾行局部或扩大手术；21例术后未行抗肿瘤治疗。无复发转移的患者有16例,43例患者有复发或转移,转移到肺部的有23例,其他部位的20例。单因素回归分析发现乳酸脱氢酶(LDH)>200 U/L、肺以外部位转移、手术范围小提示预后较差。多因素回归分析显示LDH表达水平(HR=3.045,P=0.016)为独立预后因子。Log-rank检验提示:LDH≤200 U/L、肺转移、扩大手术与患者OS呈正相关,结论 LDH水平可作为肉瘤的潜在独立预后指标。肺转移患者的OS优于其他部位转移患者,瘤床扩大切除患者相较于瘤床局部切除的患者预后更佳。 |
| 英文摘要: |
| Objective To explore the relationship between the clinical features,treatment methods and prognosis and survival of sarcoma,and to find the independent factors affecting the prognosis.Methods The clinical data and overall survival (OS) of 59 patients with sarcoma admitted to the First Affiliated Hospital of USTC from September,2018 to June,2021 were retrospectively analyzed.Univariate and multivariate cox regression was used to analyze the relationship between clinical characteristics and prognosis,Log rank Tests were performed to analyze the association of specific clinical features with OS.Results All 59 patients were histologically confirmed to be sarcoma,5 of them had no chance of surgery after diagnosis,54 had undergone local or extended surgery,and 21 had no postoperative antitumor therapy.There were 16 patients with no recurrence or metastasis,43 patients had recurrence or metastasis,23 patients had metastasized to the lung,and 20 patients had other parts.Univariate regression analysis found that dehydrogenase(LDH)>200 U/L,metastases outside the lungs,and small surgical scope indicated poor prognosis.Multivariate regression analysis showed that LDH expression level (HR=3.045,P=0.016) was an independent prognostic factor.Log rank test showed that LDH≤200 U/L,lung metastasis,and extended surgery were positively correlated with OS.Conclusions LDH level can be used as a potential independent prognostic indicator for sarcoma.The OS of patients with lung metastases is better than that of patients with metastases from other sites,and the prognosis of patients with extended tumor bed resection is better than that of patients with local tumor bed resection. |
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