| 陈丽莉,吴翔,寻英,毛盛程.肥胖2型糖尿病患者脂肪因子水平、内脏脂肪指数与血糖波动及糖尿病微血管并发症的关系[J].中国临床保健杂志,2024,(1):85-88. |
| 肥胖2型糖尿病患者脂肪因子水平、内脏脂肪指数与血糖波动及糖尿病微血管并发症的关系 |
| Relationship between adipokines,Chinese visceral adiposity index and blood glucose fluctuation,diabetic microvascular complications in patients with obesity and T2DM |
| 投稿时间：2023-11-02 |
| DOI：10.3969/J.issn.1672-6790.2024.01.017 |
| 中文关键词: 糖尿病,2型 肥胖症 糖尿病血管病变 脂肪因子类 血糖 |
| 英文关键词: Diabetes mellitus,type 2 Obesity Diabetic angiopathies Adipokines Blood glucose 〖FL |
| 基金项目: |
|
| 摘要点击次数: 40 |
| 全文下载次数: 41 |
| 中文摘要: |
| 目的 探究肥胖2型糖尿病(T2DM)患者脂肪因子镍纹样蛋白(Metrnl)、内脏脂肪指数(CVAI)与血糖波动及糖尿病微血管并发症的关系。方法 纳入2020年5月至2022年11月浙江省立同德医院收治的120例肥胖T2DM患者为研究组,其中发生微血管并发症患者作为并发症组,T2DM无微血管并发症患者作为无并发症组,并招募同期非肥胖T2DM患者100例作为对照组。比较各组Metrnl、CVAI及血糖情况,分析Metrnl水平与CVAI、血糖波动及临床指标的相关性,用logistic回归模型分析Metrnl、CVAI及血糖波动指标与微血管并发症的关系。结果 研究组体重指数和收缩压(SBP)高于对照组(P＜0.05)；并发症组病程长于无并发症组,SBP高于无并发症组(P＜0.05)。研究组Metrnl、CVAI、平均血糖标准差(SDBG)、最大血糖波动幅度(LAGE)及餐后血糖波动幅度(PPGE)高于对照组(P＜0.05),但平均血糖值(MBG)水平的比较,差异无统计学意义(P＞0.05)；并发症组Metrnl、CVAI、SDBG、LAGE及PPGE高于无并发症组(P＜0.05),MBG水平的比较,差异无统计学意义(P＞0.05)。肥胖T2DM患者血清Metrnl水平与CVAI、SDBG、LAGE及PPGE呈正相关(r=0.511、0.442、0.485、0.477,P＜0.05)。logistic回归分析结果显示,Metrnl、CVAI和LAGE是肥胖T2DM患者发生微血管并发症的独立危险因素(P＜0.05)。结论 肥胖T2DM微血管并发症患者脂肪因子Metrnl、CVAI升高,血糖波动幅度大,上述指标可作为微血管并发症的新型标志物。 |
| 英文摘要: |
| Objective To explore the relationship between adipokine,Chinese visceral adiposity index (CVAI) and blood glucose fluctuation,diabetic microvascular complications in patients with obesity and type 2 diabetes mellitus (T2DM).Methods A total of 120 patients with obesity and T2DM admitted to Tongde Hospital of Zhejiang Province were enrolled as study group between May 2020 and November 2022.According to presence or absence of microvascular complications,they were divided into complication group and non-complication group.A total of 100 patients with non obese T2DM during the same period were enrolled as control group.The serum adipokine Metrnl,CVAI and blood glucose in different groups were compared.The correlation between Metrnl and CVAI,blood glucose fluctuation,clinical indexes was analyzed.The relationship between Metrnl,CVAI,blood glucose fluctuation indexes and microvascular complications was analyzed by logistic regression model.Results The body mass index and systolic blood pressure (SBP) were higher in study group than control group (P<0.05).The course of disease was longer in complication group than non-complication group,and SBP was higher in complication group (P<0.05).Metrnl,CVAI,mean standard deviation of blood glucose (SDBG),largest amplitude of glycemic excursion (LAGE) and postprandial glucose excursion (PPGE) were higher in study group than control group (P<0.05),but difference in mean blood glucose (MBG) between the two groups was not statistically significant (P>0.05).Metrnl,CVAI,SDBG,LAGE and PPGE were higher in complication group than those of non-complication group (P<0.05),but difference in MBG between the two groups was not statistically significant (P>0.05).The level of serum Metrnl was positively correlated with CVAI,SDBG,LAGE and PPGE (r=0.511,0.442,0.485,0.477,P<0.05).The results of logistic regression analysis showed that Metrnl,CVAI and LAGE were independent risk factors of microvascular complications in obese patients with T2DM (P<0.05).Conclusion Adipokine Metrnl and CVAI are increased,and blood glucose fluctuation is greater in obese patients with T2DM and microvascular complications.The above indexes can be applied as new markers of microvascular complications. |
|
查看全文
|
| 关闭 |
|
|
|