| 李晓军,王和煦,张佳,王绩钊,朱财林,崔晓海.乳腺癌保乳术后应用3D技术填充瘤腔进行适形放疗的临床研究[J].中国临床保健杂志,2024,(1):102-105. |
| 乳腺癌保乳术后应用3D技术填充瘤腔进行适形放疗的临床研究 |
| Clinical study of 3D tumor-cavitiy-filling intensity modulated radiation therapy for breast conserving surgery |
| 投稿时间：2023-06-20 |
| DOI：10.3969/J.issn.1672-6790.2024.01.021 |
| 中文关键词: 乳腺肿瘤 乳房切除术,区段 放射疗法,适形 乳房植入 化放疗 |
| 英文关键词: Breast neoplasms Mastectomy,segmental Radiotherapy,conformal Breast implantation Chemoradiotherapy 〖FL |
| 基金项目:陕西省自然科学基础研究计划项目(2021JM-281) |
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| 中文摘要: |
| 目的 探究乳腺癌保乳术后应用3D技术填充瘤腔进行适形放疗的靶区剂量、不良反应及美容度。方法 选择2021年1月至2022年12月西安交通大学第一附属医院收治的48例乳腺癌患者,按照手术不同分为3D技术填充瘤腔组(24 例)及对照组(24例)。全部患者均开展乳腺癌根治手术治疗,仅保乳方式不同,术后实施强度调控适形放射治疗计划下的加速部分乳腺照射。结果 应用3D技术填充瘤腔保乳术后放疗的适形度指数及均匀性指数均明显高于常规保乳术后放疗(P＜0.05)。3D技术填充瘤腔保乳术后放疗的肺及心脏危及器官剂量(平均剂量),肺的V5、V10、V20、V30、V40及V50均显著低于常规保乳术后放疗组(P＜0.05)。2组患者的皮肤损伤、心律失常、骨髓抑制及消化道反应发生率差异无统计学意义。3D技术填充瘤腔保乳术后组患者的美容度要显著优于常规保乳术后患者(P＜0.05)。结论 乳腺癌保乳术后应用3D技术填充瘤腔显著增强乳腺的美容度,且不影响放疗的安全及有效性。 |
| 英文摘要: |
| Objective To explore the target dose analysis,adverse reactions and cosmetic effects of 3D technology filling the tumor cavity for conformal radiotherapy after breast-conserving surgery.Methods Forty-eight patients with breast cancer admitted to the first affiliated hospital of Xi′an Jiaotong university from January 2021 to December 2022 were selected and divided into a 3D technology filling group (24 cases) and a control group (24 cases) according to different surgeries.All patients underwent radical breast cancer surgery,with only different breast-conserving methods,followed by APBI under IMRT plan.Results The CI and HI of conformal radiotherapy after breast-conserving surgery using 3D technology filling the tumor cavity were significantly higher than those of conventional breast-conserving surgery.The lung and heart OAR doses,V5,V10,V20,V30,V40,and V50 in the 3D technology filling group were significantly lower than those in the conventional breast-conserving group.There was no significant difference in the incidence of skin damage,arrhythmia,bone marrow suppression,and gastrointestinal reaction between the two groups.The cosmetic effect of patients in the 3D technology filling group was significantly better than that in the conventional breast-conserving group.Conclusions The application of 3D technology filling the tumor cavity after breast-conserving surgery significantly enhances the cosmetic effect of the breast and does not affect the safety and effectiveness of radiotherapy. |
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