| 刘辉,刘明,陈信义,李道睿,金璿,段慧君.消化类肿瘤患者不同炎症状态下的糖代谢变化及其与血红蛋白的关系[J].中国临床保健杂志,2024,(1):124-126. |
| 消化类肿瘤患者不同炎症状态下的糖代谢变化及其与血红蛋白的关系 |
| Changes of glucose metabolism in patients with digestive tumors under different inflammatory states and their relationship with hemoglobin and significance analysis |
| 投稿时间：2023-03-27 |
| DOI：10.3969/J.issn.1672-6790.2024.01.026 |
| 中文关键词: 消化系统肿瘤 炎症 血糖 血红蛋白类 |
| 英文关键词: Digestive system neoplasms Inflammation Blood glucose Hemoglobins 〖FL |
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| 中文摘要: |
| 目的 探讨消化类肿瘤患者不同炎症状态下的糖代谢变化及其与血红蛋白(Hb)的关系。方法 回顾性分析2021年2月至2022年2月北京中医药大学附属护国寺中医医院80例消化类肿瘤患者,应用颗粒增强免疫透射比浊法对患者的C反应蛋白(CRP)水平进行检验,葡萄糖氧化酶法对患者的血糖进行检验,离子交换-高效液相色谱法对患者的糖化血红蛋白(HbA1c)水平进行检验,常规方法对血红蛋白(Hb)水平进行检测,并分析其相关性。结果 根据CRP正常水平参考值将患者分为CRP水平正常组(A组)26例、CRP水平轻中度上升组(B组)42例及CRP水平重度上升组(C组)12例；根据WHO标准中HbA1c>6.5%为糖尿病诊断标准将患者分为正常组41例、偏高组21例及确诊糖尿病组18例；根据不同CRP水平将患者分为A组、B组、C组,3组患者的CRP出现逐步升高现象(P<0.05),A组、B组空腹血糖(FPG)出现逐步升高现象,C组FPG呈现下降趋势(P>0.05),A组、B组、C组患者伴随CRP升高出现Hb下降(P<0.05)；HbA1c水平正常组、偏高组、确诊糖尿病组患者均FPG水平表现为逐步上升,但差异无统计学无意义(P>0.05),Hb水平均表现为逐步下降(P<0.05),CRP水平表现为先上升后下降趋势(P<0.05)；Pearson相关性分析显示:CRP与Hb水平呈负相关(r=-0.315,P<0.01),FPG与Hb、HbA1c均呈正相关(r=0.0.524、0.4025,P<0.01),Hb与HbA1c呈负相关(r=-0.824,P<0.001)。结论 大部分消化类肿瘤患者会出现糖代谢异常现象,炎症反应与Hb下降会随着糖代谢异常出现显著改变。 |
| 英文摘要: |
| Objective To investigate the changes of glucose metabolism in patients with digestive tumors under different inflammatory states and analyze the relationship and significance with hemoglobin (Hb).Methods Retrospective analysis was performed among 80 patients with digestive tumors in Huguosi Hospital of Traditional Chinese Medicine Affiliated to Beijing University of Traditional Chinese Medicine from February 2021 to February 2022.The C-reactive protein (CRP) level was tested by particle enhanced immunotransmission turbidimetric method,the blood glucose was tested by glucose oxidase method,and the glycocated hemoglobin (HbA1c) level was tested by ion exchange and high performance liquid chromatography method,conventional methods for detecting Hb levels,and the analysis and correlation were carried out.Results According to the reference value of normal CRP level in our hospital,the patients were divided into 26 cases of normal CRP level group (group A),42 cases of mild to moderate increase in CRP level group (group B) and 12 cases of severe increase in CRP level group (group C).According to the WHO standard of diabetes diagnosis with HbA1c>6.5%,the patients were divided into normal group (41 cases),high group (21 cases) and confirmed group (18 cases).According to different CRP levels,the patients were divided into group A,group B and group C.CRP in the three groups showed a gradual increase (P<0.05),FPG in group A and group B showed a gradual increase,FPG in group C showed a downward trend (P>0.05),and Hb in groups A,B and C showed a decrease (P<0.05) with the increase of CRP.According to different HbA1c levels,the patients were divided into normal group,high group and confirmed diabetes group.FPG level of the three groups showed a gradual increase,but no statistical significance (P>0.05),Hb level showed a gradual decrease (P<0.05),CRP level showed a downward trend after the increase (P<0.05).Pearson correlation analysis showed that CRP was negatively correlated with Hb level (r=-0.315,P<0.01),FPG was positively correlated with Hb and HbA1c (r=0.0.524,0.4025,P<0.01),and Hb was negatively correlated with HbA1c (r=-0.824,P<0.001).Conclusion Most patients with digestive tumors will have abnormal glucose metabolism,and inflammation and Hb levels change significantly with abnormal glucose metabolism. |
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