| 赵乾,庹田,李宇林,郭俊林,顾永林.老年高血压患者血清Fibulin-3水平及其在血管重构中的作用[J].中国临床保健杂志,2017,20(1):64-66. |
| 老年高血压患者血清Fibulin-3水平及其在血管重构中的作用 |
| The role of serum Fibulin-3 level on vascular remodeling in elderly patients with hypertension |
| 投稿时间：2016-07-13 |
| DOI：10.3969/J.issn.1672-6790.2017.01.020 |
| 中文关键词: 高血压 细胞外基质蛋白质类 血脂异常 肿瘤坏死因子α |
| 英文关键词: hypertension Extracellular matrix proteins Dyslipidemias Tumor necrosis factor-alpha〖FL |
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| 中文摘要: |
| 目的 观察老年高血压患者血清Fibulin-3水平,分析其在血管重构中的作用。方法 以100例正在治疗的老年高血压患者为观察对象,同时选取50例血压正常的健康老年患者为对照组。比较两组患者血清Fibulin-3、血脂、肿瘤坏死因子-α(TNF-α)、室间隔厚度(IVST)、左心室后壁厚度(LVPWT)及肱-踝脉搏波传导速度(baPWV)水平,分析Fibulin-3与血脂、TNF-α、IVST、LVPWT及baPWV的相关性。结果 高血压组患者的IVST、LVPWT水平高于对照组,Fibulin-3、LVEF和baPWV水平低于对照组,差异有统计学意义(均P<0.05)；高血压组患者的总胆固醇(TC)、低密度脂蛋白胆固醇 (LDL-C)、三酰甘油 (TG)、脂蛋白a和游离脂肪酸 (FFA)水平均高于对照组,高密度脂蛋白胆固醇 (HDL-C)水平低于对照组,均差异有统计学意义(P<0.05)；Fibulin-3与TC、LDL-C、TG、IVST、LVPWT显著负相关,与HDL-C和baPWV显著正相关,P<0.05。结论 老年高血压患者血清 Fibulin-3水平较健康老年人低,且与血脂、IVST、LVPWT、baPWV等密切相关,Fibulin-3水平降低可作为高血压患者血管重构的一项评估指标。 |
| 英文摘要: |
| Objective To observe change of the serum level of Fibulin-3 in elderly patients with hypertension,and analyze its role in vascular remodeling.Methods One hundred elderly patients with hypertension in treatment were selected as the object.At the same time,50 healthy elderly patients with normal blood pressure were selected as the control group.The level of serum Fibulin-3,serum TNF-α,IVST,LVPWT and baPWV were compared between two groups,and the correlation between Fibulin-3 and serum lipid,TNF-,IVST, LVPWT,baPWV were analyzed.Results The IVST and LVPWT of patients with hypertension were higher than those in the control group,the level of Fibulin-3,LVEF and baPWV were lower than those in control group,the difference were statistically significant(P<0.05).The level of TC,LDL-C,TG,lipoprotein A and FFA in hypertension group were higher than those in the control group,HDL-C level was lower than that of control group, the difference were statistically significant(P<0.05).The level of Fibulin-3 and TC,LDL-C,TG,IVST,LVPWT had significant negative correlation, HDL-C and baPWV had significantly positive correlation,the difference were statistically significant(P<0.05).Conclusions The level of serum Fibulin-3 in elderly patients with hypertension is lower than that of healthy control,and is closely related with blood lipids,IVST,LVPWT and baPWV,which could be considered as a useful clinic indicator for vascular remodeling. |
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