文章摘要
刘健,章平衡,万磊,等.干燥综合征患者肺功能与血小板活化之间的关系[J].中国临床保健杂志,2017,20(6):652-654.
干燥综合征患者肺功能与血小板活化之间的关系
Relationship between platelet activation and lung function in patients with sjogren′s syndrome
投稿时间：2017-06-16  
DOI：10.3969/J.issn.1672-6790.2017.06.008
中文关键词: 干燥综合征  呼吸功能试验  血小板活化
英文关键词: Sjogren′s syndrome  Respiratory function tests  Platelet activation 〖FL
基金项目:国家自然基金青年项目(81403388);安徽省自然基金项目(1508085QH159);安徽省高校自然科学基金重点项目(KJ2017A281)；安徽省重点实验室资助项目(1606c08238)
作者单位E-mail
刘健 安徽中医药大学第一附属医院风湿科,合肥 230031 liujianahzy@126.com 
章平衡 安徽中医药大学第一附属医院风湿科,合肥 230031  
万磊 安徽中医药大学第一附属医院风湿科,合肥 230031  
黄旦 安徽中医药大学第一附属医院风湿科,合肥 230031  
黄传兵 安徽中医药大学第一附属医院风湿科,合肥 230031  
张晓军 安徽中医药大学第一附属医院风湿科,合肥 230031  
孙玥 安徽中医药大学第一附属医院风湿科,合肥 230031  
刘磊 安徽中医药大学第一附属医院风湿科,合肥 230031  
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中文摘要:
      目的 探讨干燥综合征患者肺功能与血小板活化之间的关系。方法 选取干燥综合征患者66例设为观察组,同时选取健康体检者30例设为对照组。采用肺功能仪检测患者肺功能,流式细胞术检测外周血血小板分化抗原CD40 配体(CD40L)表达,魏氏法检测血小板(PLT),ELISA试剂盒检测血小板活化因子(PAF)、血小板α颗粒膜糖蛋白-140(GMP-140)、血小板源性生长因子(PDGF)的水平。结果 与对照组相比较,观察组肺功能参数明显降低,PLT、PAF、GMP-140、PDGF、CD40L水平明显升高(P<0.05)；在观察组患者中,肺功能降低的40例,占所有病例的60.61%,肺功能异常率最高为75%肺活量位的最大呼气流量(FEF75),其次是FEV1/ FVC、50%肺活量位的最大呼气流量(FEF50)、25%肺活量位的最大呼气流量(FEF25)、呼气峰流速值(PEF)。与不伴肺功能降低的SS组比较,伴肺功能降低的观察组的PLT、PAF、PDGF水平明显升高(P<0.05)。相关性分析显示:SS患者FEV1/ FVC与PDGF呈负相关,FEF25与CD40L呈负相关(P<0.01),FEF50与PAF、GMP-140呈负相关(P<0.05,P<0.01),FEF75、PEF与PLT呈负相关(P<0.05,P<0.01)。结论 干燥综合征患者存在肺功能降低,且肺功能降低与血小板活化及其活化产物的水平密切相关。
英文摘要:
      Objective To explore the relationship between platelet activation and lung function in patients with sjogren′s syndrome.Methods Sixty-six cases of SS and 30 cases of healthy control were selected.The German Jager MasterScreen automatic lung function tester was used to detect the pulmonary function parameters.Flow cytometrydetection was used to detect the CD40L.PLT was analyzed by automatic blood cell analyzer.And the levels of PAF,GMP-140 and PDGF were detected by ELISA.Results Compared to the NC group,pulmonary function parameters of RA were significantly decreased,but PLT,PAF,GMP-140,PDGF and CD40L were significantly increased (P<0.05).Forty patients with abnormal lung function,accounted for 60.61%,was observed,in which the highest abnormal lung function was FEF75,followed by FEV1/FVC,FEF50,FEF25 and PEF.Compared with SS patients without lung function reduced,PLT,PAF,and PDGF were significantly increased in SS patients with lung function reduced(P<0.05).Spearman analysis showed that FEV1/ FVC was negatively correlated with PDGF,and FEV25 was negatively correlated with CD40L(P<0.01),FEF75 and PEF were negatively correlated with PLT(P<0.05).Conclusion There is decreased lung function in patients with SS,which is closely related to platelet activation and products .
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