文章摘要
吴少华,景晔,胡艳,王兴,陈秋杰,徐和福.老年糖尿病患者血同型半胱氨酸与叶酸和维生素B12水平分析[J].中国临床保健杂志,2018,21(2):196-198.
老年糖尿病患者血同型半胱氨酸与叶酸和维生素B12水平分析
The blood homocysteine,folic acid and vitamin B12 levels analysis of elderly patients with diabetes
投稿时间：2018-01-20  
DOI：10.3969/J.issn.1672-6790.2018.02.015
中文关键词: 糖尿病  半胱氨酸  叶酸  维生素B12
英文关键词: Diabetes mellitus  Cysteine  Folic acid  Vitamin B12
基金项目:
作者单位E-mail
吴少华 中国人民解放军第四六四医院检验科,天津 300381 726962593@qq.com 
景晔 中国人民解放军第四六四医院检验科,天津 300381 xiaotian7211@sina.com 
胡艳 中国人民解放军第四六四医院检验科,天津 300381  
王兴 中国人民解放军第四六四医院检验科,天津 300381  
陈秋杰 中国人民解放军第四六四医院检验科,天津 300381  
徐和福 中国人民解放军第四六四医院检验科,天津 300381  
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中文摘要:
      目的 探讨老年糖尿病患者血清中同型半胱氨酸(Hcy)、叶酸和维生素B12(Vit B12)水平的变化及其互相关系。方法 对入选的80例糖尿病组以及80例健康对照组分别采集其清晨空腹静脉血清或血浆,-20 ℃冻存,然后集中测定血同型半胱氨酸、Vit B12、叶酸水平。 结果 糖尿病组血同型半胱氨酸的测定值明显高于健康对照组,差异有统计学意义(t=6.176,P=0.019)；同时糖尿病组叶酸及Vit B12的水平低于健康对照组,差异有统计学意义(叶酸:t=4.289,P=0.035；Vit B12:t=3.016,P=0.043)；并且血Hcy浓度与叶酸和Vit B12水平呈负相关(叶酸:r=0.920,P=0.025；Vit B12:r=0.950,P=0.013)。 结论 老年糖尿病患者血同型半胱氨酸升高的同时伴有叶酸及Vit B12的降低。
英文摘要:
      Objective To analyze the changes of serum homocysteine,folic acid and Vit B12 levels in elderly patients with diabetes and their relationship.Methods A total of 80 cases of diabetes group and 80 cases of healthy controls were collected the morning fasting venous blood serum or plasma and blood homocysteine,Vit B12,folic acid level were tested.Results Homocysteine in diabetes group was obviously higher than that of healthy controls,there was statistically significant(t=6.176,P=0.019),and folic acid and Vit B12 of diabetes group were lower than healthy controls,there were statistically significant(folic acid:t=4.289,P=0.035；Vit B12:t=3.016,P=0.043),and the Hcy concentration was negatively correlated with folate and Vit B12 levels(folic acid:r=0.92,P=0.025；Vit B12:r=0.95,P=0.013).Conclusion Blood homocysteine in elderly patients with diabetes increases with decreased folic acid and vitamin B12.
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