文章摘要
边君,万秀萍,翁惠斌,徐天才,林海,黄慧峰.内镜止血联合白眉蛇毒血凝酶注射治疗非静脉曲张性上消化道出血的效果[J].中国临床保健杂志,2018,21(3):357-359.
内镜止血联合白眉蛇毒血凝酶注射治疗非静脉曲张性上消化道出血的效果
Efficacy analysis of endoscopic hemostasis combined with Hemocoagulase injection for non variceal upper gastrointestinal bleeding
投稿时间:2018-02-27  
DOI:10.3969/J.issn.1672-6790.2018.03.019
中文关键词: 胃肠出血  静脉曲张  自然腔道内镜手术  凝血酶
英文关键词: Gastrointestinal hemorrhage  Non varicose veins  Natural orifice endoscopic surgery  Thrombin〖FL
基金项目:浙江省台州市黄岩区科技计划(2013059-19)
作者单位E-mail
边君 浙江大学衢州医院、衢州市人民医院消化内科,324000 ber85135@163.com 
万秀萍 浙江大学衢州医院、衢州市人民医院消化内科,324000  
翁惠斌 浙江大学衢州医院、衢州市人民医院消化内科,324000  
徐天才 浙江大学衢州医院、衢州市人民医院消化内科,324000  
林海 浙江大学衢州医院、衢州市人民医院消化内科,324000 dr_linhai@163.com 
黄慧峰 浙江台州市第一人民医院消化内科  
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中文摘要:
      目的 探讨内镜止血联合血凝酶注射对非静脉曲张性上消化道出血的治疗效果。方法 将150例非静脉曲张性上消化道出血患者随机数字表法分成两组,每组75例。对照组按照常规内镜止血的治疗方法,观察组同时内镜黏膜下注射白眉蛇毒血凝酶。患者病变出血征象采用 Forrest 分级,并以Rockall进行再出血和死亡危险性评分。结果 治疗后,观察组即时止血率为97.3%高于对照组89.3%,再出血率为5.3%低于对照组的16.0%,P<0.05;两组间,低危、中危者即时止血率均高于对照组,再出血率均低于对照组,P<0.05;两组间高危者的即时止血率,再出血率差异无统计学意义(P>0.05);观察组Forrest分级Ⅰ、Ⅱ级即时止血率均高于对照组(P<0.05),Forrest分级Ⅱ级再出血率低于对照组(P<0.05)。结论 内镜止血联合血凝酶注射治疗非静脉曲张性上消化道出血的疗效可靠,可迅速止血,效果优于单纯内镜止血,尤其对于Rockall 低、中危患者更为适宜。
英文摘要:
      Objective To investigate the effect of endoscopic hemostasis combined with enzyme injection on non variceal upper gastrointestinal bleeding.Methods 150 patients with non variceal upper gastrointestinal bleeding were randomly divided into two groups according to the random number table(n=75).The control group was given the treatment method of conventional endoscopic hemostasis;observation group was given endoscopic submucosal injection of hemocoagulase after endoscopic hemostasis.Results After treatment,the observation group immediate hemostasis rate was 97.3%,it was higher than that of control group (89.3%),the rate of rebleeding was 5.3%,it was lower than that of the control group(16%),P<0.05;among the patients of low risk and moderate risk in the two groups,the immediate hemostasis rate and the rate of rebleeding were all higher than that in the control group,P<0.05;while the immediate hemostasis rate and the rebleeding rate in the patients of high risk between the two groups had no significant difference,P>0.05;also in the patients of observation group the immediate hemostasis rate of Forrest grade I and grade Ⅱ were higher than that of control group (P<0.05),Forrest grade Ⅱ rebleeding rate was lower than that of the control group,P<0.05. Conclusion Endoscopic hemostasis combined with hemagglutinin injection is effective and reliable for the treatment of non variceal upper gastrointestinal bleeding.It is better than simple endoscopic hemostasis,especially for patients with low and middle risk Rockall score.
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