| 苏明萍,杨小霖,敬世霞,邓姣,袁玉红.右美托咪定联合纳布啡在胆囊切除手术患者全身麻醉苏醒期的效果[J].中国临床保健杂志,2023,26(1):66-69. |
| 右美托咪定联合纳布啡在胆囊切除手术患者全身麻醉苏醒期的效果 |
| Effect of DEX combined with nalbuphine on hemodynamics and agitation in patients undergoing cholecystectomy during general anesthesia |
| 投稿时间：2022-10-11 |
| DOI：10.3969/J.issn.1672-6790.2023.01.014 |
| 中文关键词: 胆囊切除术 麻醉,全身 苏醒谵妄 右美托咪啶 纳布啡 |
| 英文关键词: Cholecystectomy Anesthesia,general Emergence delirium Dexmedetomidine Nalbuphine 〖FL |
| 基金项目:四川省南充市社会科学研究“十三五”规划项目(NC2020B205) |
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| 中文摘要: |
| 目的 探讨右美托咪定(DEX)联合纳布啡在胆囊切除手术患者全身麻醉苏醒期的应用效果。方法 选取2021年3月15日至2022年2月25日南充市中心医院收治的116例择期行腹腔镜胆囊切除术的患者为研究对象,采用随机数字表法分为对照组(58例)和观察组(58例),分别予以纳布啡和DEX联合纳布啡。对比2组不同时间段血流动力学、苏醒质量、Ricker镇静-躁动评分(SAS)、视觉模拟评分(VAS)、呛咳程度、躁动及并发症情况。结果 T0、T3、T4、T5时,2组心率(HR)、平均动脉压(MAP)对比,差异无统计学意义(P>0.05)；T1、T2时,2组HR、MAP对比,差异有统计学意义(P<0.05)；观察组苏醒时间、拔管时间显著长于对照组(P<0.05)；苏醒时、苏醒后30 min、苏醒后60 min,观察组SAS评分、VAS评分均显著低于对照组(P<0.05)；2组1级、2级、5级呛咳程度对比,差异无统计学意义(P>0.05)；2组3级、4级对比(P<0.05)。观察组躁动及并发症发生率显著低于对照组(P<0.05)。结论 DEX联合纳布啡用于胆囊切除手术全身麻醉患者中,能够改善患者苏醒期的躁动程度,降低并发症。 |
| 英文摘要: |
| Objective To explore the effect of dexmedetomidine (DEX) combined with nabufen during the recovery period of general anesthesia for patients undergoing cholecystectomy.Methods One hundred and sixteen patients who underwent elective laparoscopic cholecystectomy in Nanchong Central Hospital from March 15,2021 to February 25,2022 were selected as the research objects,and were randomly divided into the control group (n=58) and the observation group (n=58),and nabufen and DEX combined with nabufen were selected respectively.Hemodynamics,awakening quality,Ricker Sedation-Restlessness Score (SAS),VAS score,choking degree,restlessness and complications were compared between the two groups.Results At T0,T3,T4 and T5,HR and map of the two groups were compared (P>0.05).At T1 and T2,HR and map of the two groups were compared (P<0.05).The recovery time and extubation time of the observation group were significantly longer than that of the control group (P<0.05).SAS scores and VAS scores of the observation group were significantly lower than those of the control group at the time of awakening,30min after awakening and 60 min after awakening (P<0.05).Comparison of the degree of grade 1,grade 2 and grade 5 cough between the two groups (P>0.05);Grade 3 and grade 4 were compared between the two groups (P<0.05).The incidence of agitation and complications in the observation group was significantly lower than that in the control group (P<0.05).Conclusions DEX combined with nalbuphine has sedative and analgesic effects in patients undergoing general anesthesia for cholecystectomy.It can improve the restlessness of patients during the recovery period and reduce the complications. |
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