| 李晓珺,刘盼,马丽娜.2020年国际衰弱和肌肉减少症研究会议工作组识别生物学年龄的标志物指南解读[J].中国临床保健杂志,2023,26(6):729-733. |
| 2020年国际衰弱和肌肉减少症研究会议工作组识别生物学年龄的标志物指南解读 |
| Interpretation of guideline for identifying biomarkers for biological age:2020 geroscience and the ICFSR task force |
| 投稿时间：2023-10-05 |
| DOI：10.3969/J.issn.1672-6790.2023.06.003 |
| 中文关键词: 年龄 生物标记 生物学现象 衰老 老年科学 |
| 英文关键词: Age Biomarkers Biological Phenomena Aging Geroscience 〖FL |
| 基金项目:国家重点研发计划项目(2020YFC2008604) |
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| 中文摘要: |
| 衰老与癌症、心血管疾病、呼吸道疾病、内分泌代谢和神经退行性改变等多种疾病密切相关。可量化生物学年龄的标志物在探索衰老的生物学机制、识别生物学年龄、延缓衰老、维持功能和预防衰弱甚至死亡方面具有重要作用。为进一步探索衰老的生物学机制和识别生物学年龄,2020年国际衰弱和肌肉减少症研究会议工作组发布了关于可识别生物学年龄的生物标志物指南,探讨了9种潜在的衰老生物标志物和衰弱组学标志物,旨在提供识别和量化生物学年龄的统一标准,促进老年科学的跨学科发展。现对该指南中衰老的生物学机制和相应生物标志物方面内容进行解读,以期为识别我国老年人群生物学年龄提供参考。 |
| 英文摘要: |
| Aging is closely associated with cancer,cardiovascular disease,respiratory disease,endocrine metabolism disease and neurodegeneration.The biomarkers which can quantify biological age play important roles in exploring the biological mechanism of aging,identifying biological age,delaying senescence,maintaining function,and preventing frailty and death.The International Conference on Frailty and Sarcopenia Research (ICFSR) Task Force published a guideline in 2020,which raised nine hallmarks of aging and biological markers,aiming to provide standards for identifying biological age and advancing the interdisciplinary field of geroscience.This review interprets the biological mechanisms of aging and their biomarkers,to better identify biological age in the Chinese older adults. |
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