| 刘丹,董艳娟,周冬翠,邢建丽,何跃,张法军.慢性脑供血不足患者认知功能与S100β蛋白、同型半胱氨酸水平的相关性[J].中国临床保健杂志,2016,(4):360-362. |
| 慢性脑供血不足患者认知功能与S100β蛋白、同型半胱氨酸水平的相关性 |
| Correlation of montreal cognitive assessment and S100β protein,homocysteine in patients of chronic cerebral circulation insufficiency with cognitive impairment |
| 投稿时间：2015-09-07 |
| DOI：10.3969/J.issn.1672-6790.2016.04.008 |
| 中文关键词: 脑缺血 认知障碍 半胱氨酸 S100蛋白质类 危险因素 |
| 英文关键词: Brain ischemia Cognition disorders Cysteine S100 proteins Risk factors〖FL |
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| 中文摘要: |
| 目的 探讨S100β蛋白、同型半胱氨酸(Hcy)水平与慢性脑供血不足 (CCCI) 患者认知功能水平的相关性。 方法 选择48例CCCI患者作为CCCI组,46例健康体检者作为健康对照组,对CCCI组和健康对照组进行综合检测评分,认知功能水平检测采用蒙特利尔认知评估量表(MoCA),并进行血液指标S100β蛋白及Hcy检测。结果 CCCI组患者认知功能障碍发生率为72.91%(35/48),明显高于健康对照组的发生率21.73%(10/46)(P<0.01)。CCCI组S100β蛋白、Hcy含量均高于健康对照组(P<0.05)。CCCI组S100β蛋白、Hcy含量与MoCA评分呈负相关(P<0.05)；S100β蛋白、Hcy未见明显线性相关(P>0.05)。 结论 CCCI组患者认知功能障碍发生率高；S100β蛋白、Hcy可能参与CCCI的发生和发展；S100β蛋白、Hcy可能是影响CCCI患者认知功能的2个相互独立的因素。 |
| 英文摘要: |
| Objective To explore the correlation of montreal cognitive assessment (MoCA)and S100β protein、Homocysteine(Hcy)in patients of chronic cerebral circulation insufficiency (CCCl) with cognitive impairment.Methods Forty-eight patients with CCCl were as CCCl group,while 46 healthy subjects were as control group.The cognitive function and the level of S100β protein、Hcy were detected.Results The incidence (72.91％, 35/48) of cognitive impairment of CCCl group was significantly higherthan control group (21.73％, 10/46)(P<0.01).The concentration of S100β protein and Hcy of CCCl group was higher than control group (P<0.05).The MoCA score of CCCl group was negative relationship with S100β protein and Hcy.No relationship was found between S100β protein and Hcy.Conclusions Patients with CCCI have a higher incidence of cognitive impairment. S100β protein and Hcy are important risk factors of CCCl occurrence.S100β protein and Hcy maybe the separate risk factors of cognitive impairment. |
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