文章摘要
洪玲,吴天学,石立新,孙金明,张红.谷氨酰胺联合亚胺培南对重症急性胰腺炎合并感染患者炎性反应的影响[J].中国临床保健杂志,2017,20(1):26-27.
谷氨酰胺联合亚胺培南对重症急性胰腺炎合并感染患者炎性反应的影响
Inflence of glutamine combined imipenem on blood routine and inflammatory factors of acute severe pancreatitis patients with infection
投稿时间：2016-05-22  
DOI：10.3969/J.issn.1672-6790.2017.01.009
中文关键词: 胰腺炎,急性坏死性  谷氨酰胺  亚胺培南  感染
英文关键词: Pancreatitis,acute necrotizing  Glutamine  Imipenem  Infection〖FL
基金项目:江苏省卫生厅医学科研立项课题(Y2013042)
作者单位E-mail
洪玲 江苏扬州市江都人民医院检验科,225000 hongling_1979@medicine360.net 
吴天学 苏北人民医院医学检验中心基因诊断实验室  
石立新 江苏扬州市江都人民医院检验科,225000  
孙金明 江苏扬州市江都人民医院检验科,225000  
张红 江苏江阴市中医骨伤医院检验科  
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中文摘要:
      目的 探讨谷氨酰胺联合亚胺培南对急性重症胰腺炎并感染患者炎性反应的影响。方法 选取116例急性重症胰腺炎合并感染患者,采用分层随机分组分为观察组和对照组,每组58例。对照组治疗中使用了亚胺培南进行治疗,观察组在对照组的基础上联合谷氨酰胺进行治疗。观察两组患者治疗前后白细胞计数、血小板计数、C反应蛋白(CRP)、血浆内毒素水平(LPS)水平的变化情况,及两组的临床疗效。结果 治疗后,两组白细胞计数、血小板计数、CRP、LPS水平显著改善,且观察组白细胞计数、血小板计数、CRP、LPS水平改善情况优于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率为75.9%,显著优于对照组的56.9%,差异有统计学意义(χ2=6.396,P<0.05)。结论 谷氨酰胺联合亚胺培南可有效改善急性重症胰腺炎并感染患者的炎性反应水平。
英文摘要:
      Objective To investigate the inflence of glutamine combined imipenem on blood routine and inflammatory factors of acute severe pancreatitis patients with infection.Methods 116 cases of severe acute pancreatitis with infection patients were divided into observation group and control group by stratified randomization,58 cases in each group.The control group was treated with imipenem,and observation group was combined glutamine based on control group.Before and after treatment,the changes on blood routine (white blood cell count,platelet count),inflammatory cytokines(CRP),plasma endotoxin(LPS) levels of two groups were observed.And the clinical effect of two groups were accounted.Results After treatment,the white blood cell count,platelet count,CRP and LPS levels of the two groups were significantly improved,and the improvement on white blood cell count,platelet count,CRP and LPS of observation group were better than those of control group,the differences were statistically significant (P<0.05).The total effective rate of observation group was 75.9%,which was significantly higher than that of control group 56.9%,the difference was statistically significant(χ2=6.396,P<0.05).Conclusion Glutamine combined imipenem can effectively improve the blood routine and inflammatory factors of severe acute pancreatitis with patients infection.
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