| 塔吉古丽·木沙,向红,白雪,李杨静,王红梅.RANK基因甲基化与新疆不同民族老年男性高密度脂蛋白胆固醇的相关性[J].中国临床保健杂志,2018,21(6):735-738. |
| RANK基因甲基化与新疆不同民族老年男性高密度脂蛋白胆固醇的相关性 |
| Correlation between RankANK gene DNA methylation and high density lipoprotein cholesterol in male Elderly Uygur,Kazak and Han Nationality in Xinjiang |
| 投稿时间：2018-06-19 |
| DOI：10.3969/J.issn.1672-6790.2018.06.004 |
| 中文关键词: 胆固醇,HDL DNA甲基化 民族 老年人 |
| 英文关键词: Cholesterol,HDL DNA methylation Ethnic groups Aged 〖FL |
| 基金项目:新疆维吾尔自治区自然科学基金项目(2015211C199) |
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| 中文摘要: |
| 目的 探讨RANK基因甲基化与高密度脂蛋白胆固醇(HDL-C)的相关性。方法 2018年4月至2018年5月对新疆木垒县和洛浦县65岁以上的汉族、维吾尔族、哈萨克族居民流行病学调查研究数据,分为病例组和对照组进行研究。调查采用问卷调查、体格检查和实验室检测获取研究对象的一般资料及血生化指标。应用EpiTect Fast Bisulfite Conversion Kits进行基因组甲基化修饰,采用BiQ Analyzer 分析软件对RANK基因组标准序列和测序序列进行比对。采用协方差分析,在校正年龄、吸烟、饮酒及高血压、糖尿患病率后,分析对照组、病例组RANK基因CpG岛甲基化率。结果 在新疆维吾尔族、哈萨克族老年男性中,对照组RANK基因CpG岛甲基化率低于病例组,差异有统计学意义(P<0.05)；校正年龄、吸烟、饮酒及高血压、糖尿病、肥胖患病率后,在新疆维吾尔族、哈萨克族老年男性中,对照组RANK基因CpG岛甲基化率低于病例组,差异有统计学意义(P<0.05)。结论 在新疆维吾尔族、哈萨克族老年男性中,RANK基因甲基化率增高可能与低高密度脂蛋白胆固醇血症相关。 |
| 英文摘要: |
| Objective To investigate the correlation between RANK gene methylation and high-density lipoprotein cholesterol (HDL-C) by case-control study.Methods Data were collected from the epidemiological survey data of Han,Uygur,Kazak residents aged 65 and over in luopu county,mulei county,xinjiang from April 2018 to May 2018,which were divided into case group and control group.General information and blood biochemical indexes of the subjects were obtained by questionnaire survey and laboratory test.The genomic methylation modification was performed on EpiTect Fast Bisulfite Conversion Kits,BiQ Analyzer was used to compare the RANK genome standard sequence and sequencing sequence.The methylation rate of RANK gene CpG island in the control group was analyzed by covariance analysis after adjusting the prevalence rate of age,smoking,drinking and hypertension and diabetes.Results Among elderly uygur,kazak nationality males of xinjiang,The methylation rate of RANK gene CpG island in the control group was lower than that in the case group,The difference was statistically significant(P<0.05).After adjusting the prevalence rate of age,smoking,drinking and hypertension and diabetes,Among elderly uygur,kazak nationality males of xinjiang,The methylation rate of RANK gene CpG island in the control group was lower than that in the case group (P<0.05).Conclusion Among elderly uygur,kazak nationality males of xinjiang,a slight increase in RANK methylation may be associated with low HDL cholesterol. |
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