| 董文哲,刘健,忻凌,方妍妍,文建庭.基于数据挖掘的老年类风湿关节炎患者血小板参数变化及关联规则分析[J].中国临床保健杂志,2020,23(1):51-55. |
| 基于数据挖掘的老年类风湿关节炎患者血小板参数变化及关联规则分析 |
| Platelet parameter changes and association rules analysis in elderly patients with rheumatoid arthritis based on data mining |
| 投稿时间：2018-02-06 |
| DOI：10.3969/J.issn.1672-6790.2020.01.012 |
| 中文关键词: 关节炎,类风湿 血小板 老年人 数据挖掘 |
| 英文关键词: Arthritis,rheumatoid Blood platelets Aged Data mining |
| 基金项目:国家自然科学基金(81403388)；安徽省自然科学基金(1508085QH159)；中医药行业科研专项(201307001)；2016年中央引导地方科技发展专项(财教〔2016〕1188)；安徽省科技攻关项目(1604a0802085)；现代中医内科应用基础与开发研究安徽省重点实验室(财教〔2016〕518)；2015年技术创新服务体系专项(财教〔2015〕1551) |
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| 中文摘要: |
| 目的 运用关联规则等统计学方法分析老年类风湿关节炎(RA)患者血小板参数的变化及其与其他实验室指标的相关性。方法 收集并整理2012 年6月至2016年12月在安徽省中医院风湿免疫科住院的确诊RA 4 073例的病历资料,以年龄是否大于60岁分为老年组(≥60岁)和中青年组(＜60岁),采用SPSS 21.0软件对患者血清血小板参数[血小板计数(PLT)、血小板分布宽度(PDW)、血小板平均体积(MPV)、血小板压积(PCT)、大型血小板比率(P-LCR)]、免疫指标[免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、免疫球蛋白G(IgG)、补体C3、补体C4]、炎性指标[类风湿因子(RF)、红细胞沉降率(ESR)、C反应蛋白(CRP) 、白细胞计数(WBC)]、代谢指标[超氧化物歧化酶(SOD)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)]等实验室指标进行相关性分析,并通过SPSS Clementine 11.1 软件Aprior 模块分析血小板参数、凝血、免疫、炎症、代谢等实验室指标与年龄的关系。结果 (1)1 520例老年RA患者PLT值与正常参考值(125×109/L ~350×109/L) 相比较,正常的有1 221例(80.33%),异常的有299例(19.67%),2 553例中青年组患者PLT值正常的有2113例(82.77%),异常的有440例(17.23%)。(2)两组异常率相比较,老年组PDW、MPV、HDL-C降低较青年组明显(P＜0.05 或P＜0.01),PCT、P-LCR、ESR、CRP、IgA、 IgM、IgG 、C3、C4、TG升高较青年组明显(P＜0.05 或P＜0.01)。(3)PLT与CRP 呈正相关(P＜0.05 或P＜0.01),与其他指标及年龄无相关性(P＞0.05)；PDW 与年龄、IgM、IgG、C3、TG、TC呈负相关(P＜0.05 或P＜0.01),与其他所选实验室指标无相关性(P＞0.05)；MPV与年龄、IgM、IgG、C3、TG、TC呈负相关(P＜0.05 或P＜0.01),与其他指标无相关性(P＞0.05)；PCT与年龄、IgM、IgG、C3、TG呈负相关(P＜0.05 或P＜0.01),与其他指标无相关性(P＞0.05)。(4)设定最小置信度为70%,最小支持度为20%。经Aprior 模块分析,分别列出与PLT升高、PCT升高置信度、支持度较高的指标。得出PLT关联于C3(置信度83.67%,支持度26.84%),PLT关联于IgG (置信度85.23%,支持度25.71%),PLT关联于超敏C反应蛋白(hs-CRP) (置信度78.75%,支持度27.39%),PLT关联于RF(置信度77.14%,支持度36.72%),PLT关联于C4(置信度80.38%,支持度39.55%)。PCT关联于IgG(置信度78.51%,支持度27.25%),PCT关联于ESR(置信度81.36%,支持度29.87%)。结论 老年RA 患者血清PLT参数显著升高,PLT可能参与了RA的发生与发展。PLT参数的异常可能对老年RA患者炎症、代谢、免疫的紊乱有一定的影响。 |
| 英文摘要: |
| Objective To analyze the changes of peripheral blood platelet parameters in elderly patients with rheumatoid arthritis(RA) and its correlation with other laboratory parameters by statistical methods such as association rules.Methods The records of patients with confirmed RA who were admitted to the Department of Rheumatology and Immunology of the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine from June 2012 to December 2016 were collected and sorted into the elderly group (≥60 years old) and young and middle-aged patients (<60 years old).Peripheral blood platelet parameters (PLT,PDW,MPV,PCT,P-LCR),immune markers (IgA,IgM,IgG,complement C3 and complement C4),inflammatory markers[rheumatoid factor (RF),Erythrocyte sedimentation rate (ESR),C-reactive protein (CRP),white blood cell count (WBC),and the metabolic indexes of superoxide dismutase (SOD),triglyceride (TG),total cholesterol (TC),HDL-C,LDL-C,ApoA1 and ApoB were analyzed by SPSS 21.0.And analysis of platelet parameters,coagulation,Immunology,inflammation,metabolism and other laboratory indicators and the relationship between age through the SPSS Clementine 11.1 software Aprior module.Results (1) The PLT value of 1520 elderly patients with RA was 1221 (80.33%) normal and 299 (19.67%) abnormal compared with the normal reference value (125×109/L-350×109/L) There were 2113 patients (82.77%) with normal PLT values in the youth group and 440 patients (17.23%) with abnormalities.(2) Compared with the young group,the PDW,MPV and HDL-C in the elderly group were significantly lower than those in the young group (P<0.05 or P<0.01).The PCT,P-LCR,ESR,CRP,IgA,IgM,C3,C4,TG increased significantly than the young group (P<0.05 or P<0.01).(3) There was no significant correlation between PLT and CRP(P<0.05 or P<0.01),and no correlation with other indexes and age(P>0.05).PDW was negatively correlated with age,IgM,IgG,(P<0.05 or P<0.01),but no correlation with other selected laboratory parameters(P>0.05).There was a negative correlation between MPV and age,IgM,IgG(P<0.05 or P<0.01).PCT was negatively correlated with age,IgM,IgG,C3 and TG (P<0.05 or P<0.01),but no correlation with other indexes (P>0.05).(4) set the minimum confidence of 70 percent,the minimum support of 20 percent.The Aprior module analysis,respectively,with the increase of PLT,PCT increased confidence,higher support index.PLT was associated with C3 (confidence level 83.67 percent,support level 26.84 percent),PLT was associated with IgG (confidence level 85.23 per cent,support level 25.71 percent),PLT was associated with hs-CRP (confidence level 78.75 percent,support level 27.39 percent),PLT was associated with RF (confidence 77.14 percent,support 36.72 percent),and PLT was associated with C4 (confidence 80.38 percent,support 39.55 percent).PCT was associated with IgG (confidence 78.51 percent,support 27.25 percent),PCT associated with ESR (confidence 81.36 percent,support 29.87 percent).Conclusions Peripheral blood PLT parameters are significantly elevated in elderly patients with RA,PLT may be involved in the occurrence and development of RA.Abnormalities of PLT parameters may have some impact on inflammation,metabolism and immune disorders in elderly patients with RA. |
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