| 张超男,郭红,朱琦,张烈,俞兰,何挺,孟伟峰.小剂量丙戊酸联合奥卡西平治疗老年癫痫患者46例疗效分析[J].中国临床保健杂志,2020,23(1):94-96. |
| 小剂量丙戊酸联合奥卡西平治疗老年癫痫患者46例疗效分析 |
| Effect of low-dose valproic acid combined with oxcarbazepine on electroencephalogram in elderly patients with epilepsy |
| 投稿时间：2019-08-24 |
| DOI：10.3969/J.issn.1672-6790.2020.01.021 |
| 中文关键词: 癫痫 脑电描记术 丙戊酸 奥卡西平 老年人 |
| 英文关键词: Epilepsy Electroencephalography Valproic acid Oxcarbazepine Aged |
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| 中文摘要: |
| 目的 分析小剂量丙戊酸联合奥卡西平对老年癫痫患者的疗效。方法 选取92例老年癫痫患者,根据不同治疗方案将其纳入奥卡西平组(46例)与丙戊酸+奥卡西平组(46例)。奥卡西平组予以奥卡西平治疗,丙戊酸+奥卡西平组予以小剂量丙戊酸联合奥卡西平治疗。对比两组患者的癫痫发作情况(发作次数、发作持续时间)、临床疗效、脑电图变化(痫样放电、累及导联数)、脑电图改善效果。结果 丙戊酸+奥卡西平组的癫痫发作次数与发作持续时间[(0.45±0.17)次/月、(1.21±0.56)分钟/次]均少于奥卡西平组[(0.86±0.33)次/月,(2.25±0.84)分钟/次)],P<0.05;丙戊酸+奥卡西平组的总有效率(93.48%)高于奥卡西平组(78.26%),P<0.05;丙戊酸+奥卡西平组治疗后脑电图的痫样放电与累及导联数[(7.38±1.43)t/180 s、(3.45±1.29)/180s]均优于奥卡西平组[(10.20±2.16)t/180s、(5.50±1.52)/180s),P<0.05;丙戊酸+奥卡西平组的脑电图总改善率(91.30%)高于奥卡西平组(73.91%),P<0.05。结论 小剂量丙戊酸联合奥卡西平对老年癫痫患者的疗效显著,可明显减少癫痫发作次数与发作持续时间。 |
| 英文摘要: |
| Objective To analyze the effect of low-dose valproic acid combined with oxcarbazepine on electroencephalogram (EEG) in elderly patients with epilepsy.Methods Ninety-two elderly patients with epilepsy diagnosed were enrolled in group A (46 cases) and group B(46 cases) according to different treatment schemes.Group A was treated with oxcarbazepine,and group B was treated with low-dose valproic acid combined with oxcarbazepine.The epileptic seizures (seizure frequency,duration of seizures),clinical efficacy and electroencephalogram changes were compared between the two groups.Improvement of electroencephalogram (EEG) and electroencephalogram (ECG).Results The number and duration of epileptic seizures in group B[(0.45±0.17) times per month,(1.21±0.56) minutes per time] were less than those in group A[ (0.86±0.33)times per month,(2.25±0.84)minutes per time],P<0.05;the total effective rate in group B (93.48%) was higher than that in group A (78.26%),P<0.05;the number of epileptic discharge and involvement leads in group B [(7.38±1.43)t/180s,(3.45±1.29)/180s] were better than those in group A [(10.20±2.16)t/180s,(5.50±1.52)/180s],P<0.05;The total improvement rate of EEG in group B (91.30%) was higher than that in group A (73.91%),P<0.05.Conclusion Low dose valproic acid combined with oxcarbazepine is effective in the treatment of senile epilepsy.It can significantly reduce the number and duration of epileptic seizures and improve EEG. |
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