| 孙广瀚,刘健,龙琰,鲍丙溪,张颖.基于数据挖掘分析中医健脾单元疗法对痛风患者代谢指标的影响及其干预研究[J].中国临床保健杂志,2020,23(2):182-187. |
| 基于数据挖掘分析中医健脾单元疗法对痛风患者代谢指标的影响及其干预研究 |
| Analysis of the influence of TCM invigorating spleen unit therapy on metabolic index of gout patients based on data mining and its intervention study |
| 投稿时间：2019-04-11 |
| DOI：10.3969/J.issn.1672-6790.2020.02.010 |
| 中文关键词: 痛风 从脾胃论治 半胱氨酸 尿酸 中成药 数据挖掘 |
| 英文关键词: Gout Treat Regulat Spleen Stomach Cysteine Uric acid Chinese Patent Drugs Data mining 〖FL |
| 基金项目:国家自然科学基金项目(81403388,81503558)；国家自然基金青年项目(81403388)； 2016年中央引导地方科技发展专项(财教〔2016〕1188)；现代中医内科应用基础与开发研究安徽省重点实验室项目(财教〔2016〕518)；安徽高校自然科学研究重点项目(KJ2017A281) |
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| 中文摘要: |
| 目的 运用随机行走模型评价中医健脾单元疗法对痛风(Gout)患者代谢指标的影响。方法 利用安徽中医药大学第一附属医院住院病历数据处理系统采集患者信息,研究其代谢指标:同型半胱氨酸(Hcy)与尿酸(UA)。收集并整理该院风湿免疫科2012 年6 月至2018年12月Gout住院患者。依据是否使用黄芩清热除痹胶囊分为单元疗法组和单纯中药组,利用随机行走模型和关联规则评价中医健脾单元疗法对Gout患者Hcy和UA影响。结果 ①共纳入274例Gout患者符合研究要求,单纯中药组为106例(38.69%),单元疗法组168例(61.31%)。基于四性和五味的中医理论,其中寒性草药(出现110次,37.7%),温性(出现89次,30.5%)和凉性的(出现18次,6.2%)是使用频率排名前三的草药。②经关联规则分析:在同样使用黄芩清热除痹胶囊情况下,Hcy降低与蒲公英、泽兰、泽泻、黄柏、威灵仙、车前草升高呈关联,UA降低与山慈菇、川牛膝、泽泻、黄柏、车前草、桃仁、红花、丹参升高呈关联。③随机行走模型显示:单元疗法组UA临床意义在于UA每改善一步,需要行走7.53步；而单纯中药组UA临床意义在于UA每改善一步,需要行走2.06步。单元疗法组临床意义在于Hcy每改善一步,需要行走3.39步。④聚类分析共聚为3类,聚1类有桃仁、红花、丹参、茯苓、陈皮、甘草、蒲公英；聚2类山药、白术、薏苡仁、垂盆草、泽兰、山慈菇、黄柏、车前草、泽泻、土茯苓、川牛膝、威灵仙；聚3类郁金。结论 中医健脾单元疗法对患者炎性指标的改善效果优于单纯中药内服。中医健脾单元疗法治疗痛风有良好的效果。 |
| 英文摘要: |
| Objective To evaluate the effect of TCM spleen unit therapy on metabolic indexes in patients with gout by using random walk model. Methods The patient information was collected by the inpatient medical record data processing system of the First Affiliated Hospital of Anhui University of Chinese Medicine,and its metabolic indicators were studied.According to whether the traditional Chinese medicine decoction and the in-hospital preparation of Huangqi Qingre Bucho Capsule were divided into unit therapy group and simple Chinese medicine group,the random walk model and association rule were used to evaluate the traditional Chinese medicine spleen unit therapy on plasma Hcy and UA impact for Gout patients.Results 1.A total of 274 patients with Gout met the study requirements,106 (38.69%) in the traditional Chinese medicine group and 168(61.31%) in the unit therapy group.Based on the four-sex and five-flavored theory of traditional Chinese medicine,among which cold herbs (110 occurrences,37.7%),mildness (89 occurrences,30.5%) and coolness (18 occurrences,6.2%) were the top three in terms of frequency 2 Analysis of association rules:Under the same conditions of using Huangqi Qingre Bucho capsules,the decrease of Hcy was associated with the increase of dandelion,Zeeland,Alisma,Phellodendron,Clematis,and plantain,and UA decreased with Shanci Mushroom and Sichuan.Achyranthes,Astragalus,Cork,Plantain,Peach Kernel,Safflower,and Salvia miltiorrhiza are associated.3 Random walk model showed that the clinical significance of UA in unit therapy group is that UA needs to walk 7.53 steps for each step of improvement.The clinical significance of UA in traditional Chinese medicine group is that UA needs to walk 2.06 steps for each improvement step.The clinical significance of the unit therapy group is that Hcy needs to walk 3.39 steps for each improvement step.4 Cluster analysis analysis of 3 types,poly 1 type have peach kernel,safflower,salvia,medlar,tangerine peel,licorice,dandelion;poly 2 yam,Atractylodes,Coix seed,Sedum,Zeeland,Shanci mushroom,Cork,plantain,Alisma,bandit,Sichuan Achyranthes,Clematis;poly-3-types of turmeric.Conclusion There is a long-term correlation between the comprehensive evaluation indexes of the two groups of patients and the interventions received.The improvement of inflammatory index of patients with TCM spleen unit therapy is better than that of traditional Chinese medicine.TCM spleen unit therapy has a good effect in treating gout. |
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