| 徐将,祝捷,杨光伟,黄斌,许琳琳,孙建然,王炜,陈燕,叶山东.初诊断2型糖尿病患者糖化血红蛋白水平与胰岛α细胞及β细胞功能的相关性[J].中国临床保健杂志,2020,23(4):487-490. |
| 初诊断2型糖尿病患者糖化血红蛋白水平与胰岛α细胞及β细胞功能的相关性 |
| Relationship between different HbA1c levels and islet α-cell and β-cell function in newly diagnosed patients with type 2 diabetes mellitus |
| 投稿时间：2019-12-09 |
| DOI：10.3969/J.issn.1672-6790.2020.04.013 |
| 中文关键词: 糖尿病,2型 糖基化血红蛋白A 胰岛 |
| 英文关键词: Diabetes mellitus,type 2 Glycated hemoglobin A Islets of langerhans |
| 基金项目:中央引导地方科技发展专项资金项目(2017070802D147) |
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| 中文摘要: |
| 目的 了解不同糖化血红蛋白(HbA1c)水平初诊断2型糖尿病患者胰岛α细胞及β细胞功能状况。方法 取2014年1月至2018年12月在安徽省立医院住院的初诊断2型糖尿病患者106例,按HbA1c水平分为3组:A组为7.0≤HbA1c<9.0%,B组为9.0≤HbA1c<11.0%,C组为HbA1c≥11.0%。联合进行标准馒头餐-胰岛素、胰高血糖素释放试验,比较各组间胰岛素、胰高血糖素、胰岛素抵抗指数、胰岛β细胞分泌指数、糖负荷后30 min胰岛素与血糖的净增值比值(ΔI30/ΔG30)、胰岛素曲线下面积(AUCI)、胰高血糖素曲线下面积(AUCGL)的变化,并对HbA1c与胰岛α细胞及β细胞功能指标进行相关性分析。结果 三组间年龄、性别、病程、体质指数及血压差异无统计学意义。与A组相比,B组和C组空腹血糖、总胆固醇、三酰甘油及低密度脂蛋白均明显升高。随着HbA1c水平升高,空腹及餐后各时相胰高血糖素、胰高血糖素曲线下面积均逐渐升高,胰岛β细胞分泌指数(HOMA-β)、ΔI30/ΔG30、AUCI均明显降低。结论 随着HbA1c水平升高,初诊断2型糖尿病患者胰岛β细胞分泌功能逐步减退同时存在α细胞功能紊乱加重。 |
| 英文摘要: |
| Objective To investigate the function of islet α-cell and β-cell among patients with newly diagnosed type 2 diabetes mellitus at different HbA1c levels.Methods 106 inpatients with newly diagnosed type 2 diabetes mellitus were divided into three groups according to HbA1c levels:group A (7.0≤HbA1c<9.0%),group B (9.0≤HbA1c<11.0%),and group C (HbA1c≥11.0%).Standard steamed bread meal-insulin and glucagon release tests were performed to observe the differences in insulin,glucagon,HOMA-IR,HOMA-β,ΔI30ΔG30,area under curve of insulin (AUCI),area under curve of glucagon (AUCGL) among three groups,and a correlation analysis was performed between HbA1c and the function of islet α-cell and β-cell.Results There were no significant differences in age,sex,course of disease,body mass index and blood pressure among the three groups.Compared with group A,fasting blood glucose,total cholesterol,triglyceride and low density lipoprotein in group B and C increased significantly (P<0.05).With the increase of HbA1c level,the levels of glucagon,AUCGL gradually increased,HOMA-β,ΔI30/ΔG30,and AUCI decreased.Conclusion With the increase of HbA1c levels,insulin secretion of β-cell decreased gradually and glucagon secretion of α-cell increased constantly in patients with newly diagnosed type 2 diabetes mellitus. |
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