| 李祥,张超,李庆睿,周双勤.血清乳酸、可溶性髓样细胞触发受体-1、降钙素原水平变化与老年重症肺炎患者急性生理慢性健康评分的相关性及临床意义[J].中国临床保健杂志,2023,26(1):105-108. |
| 血清乳酸、可溶性髓样细胞触发受体-1、降钙素原水平变化与老年重症肺炎患者急性生理慢性健康评分的相关性及临床意义 |
| Correlation and clinical significance of changes of levels of blood lactic acid,sTREM-1 and PCT with score of APACHE Ⅱ in elderly patients with severe pneumonia |
| 投稿时间：2022-11-23 |
| DOI：10.3969/J.issn.1672-6790.2023.01.023 |
| 中文关键词: 肺炎 乳酸 髓系细胞触发受体-1 降钙素原 老年人 |
| 英文关键词: Pneumonia Lactic acid Triggering receptor expressed on myeloid cells-1 Procalcitonin Aged 〖FL |
| 基金项目:国家自然科学基金项目(82003972) |
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| 中文摘要: |
| 目的 探讨血清乳酸(血乳酸)、可溶性髓样细胞触发受体-1(sTREM-1)、降钙素原(PCT)水平变化与老年重症肺炎患者急性生理学与慢性健康状态评分(APACHE Ⅱ)的相关性及临床意义。方法 回顾性收集2019年1月至2021年12月北京市门头沟区医院收治的100例老年肺炎患者临床资料,选取同期同一医院进行体检的100例老年健康体检者体检资料作为健康对照组,统计2组一般资料,比较健康对照组及不同病情严重程度老年肺炎患者、不同预后老年肺炎患者血清细胞因子水平及APACHE Ⅱ评分,采用Pearson相关系数模型分析老年重症肺炎患者血清细胞因子水平与APACHE Ⅱ评分的相关性。结果 血乳酸、血清sTREM-1、PCT水平及APACHE Ⅱ评分比较,重症组高于轻症组和健康对照组,轻症组高于健康对照组(P<0.05)。不同预后老年肺炎患者血乳酸、血清sTREM-1、PCT水平及APACHE Ⅱ评分比较,死亡组高于存活组(P<0.05)。Pearson相关性分析结果显示,老年重症肺炎患者血清乳酸、sTREM-1、PCT水平与APACHE Ⅱ评分呈正相关关系(r=0.783、0.692、0.885,P<0.05)。结论 老年肺炎患者血乳酸、血清sTREM-1、PCT水平及APACHE Ⅱ评分随着患者病情严重程度增加而升高,血乳酸、血清sTREM-1、PCT水平与老年重症肺炎患者APACHE Ⅱ评分呈正相关关系,可用于患者病情严重程度和预后的预测。 |
| 英文摘要: |
| Objective To analyze the correlation and clinical significance between the changes of levels of serum lactic acid (blood lactic acid),soluble myeloid trigger receptor-1 (sTREM-1) and procalcitonin (PCT) and score of acute physiological and chronic health score (APACHE Ⅱ) of elderly patients with severe pneumonia.Methods The clinical data of 100 elderly patients with pneumonia admitted to Mentougou District Hospital from January 2019 to December 2021 were retrospectively collected.The physical examination data of 100 elderly health examinees in the same hospital in the same period were selected as the healthy control group,and the general data of the two groups were counted.The levels of serum cytokine and score of APACHE Ⅱ of the healthy control group,elderly pneumonia patients with different severity and different prognosis were compared.Pearson correlation coefficient model was used to analyze the correlation between levels of serum cytokine and score of APACHE Ⅱ of elderly patients with severe pneumonia.Results The levels of blood lactic acid and serum sTREM-1 and PCT and score of APACHE Ⅱ of the three groups were higher in severe group than those in the mild illness group and the healthy control group,while those in the mild illness group were higher than those in the healthy control group (P<0.05).The levels of serum lactic acid,sTREM-1,PCT and score of APACHE Ⅱ in elderly patients with pneumonia with different prognosis were higher in the death group than in the survival group (P<0.05).Pearson correlation analysis showed that levels of blood lactic acid and serum sTREM-1 and PCT in elderly patients with severe pneumonia were correlated with score of APACHE Ⅱ (r=0.783,0.692,0.885,P<0.05).Conclusions The levels of blood lactic acid,sTREM-1 and PCT and score of APACHE Ⅱ in elderly patients with severe pneumonia increased with the severity of the disease.The levels of blood lactic acid and serum sTREM-1 and PCT were correlated with score of APACHE Ⅱ in elderly patients with severe pneumonia,which could be used to predict the severity of the disease and prognosis of patients. |
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