| 张岭,厉彦超,赵笑颜,于岩,周津,陈照立.MicroRNA-210在缺血性脑卒中中的作用研究进展[J].中国临床保健杂志,2023,26(2):151-157. |
| MicroRNA-210在缺血性脑卒中中的作用研究进展 |
| Research progress on the role of MicroRNA-210 in ischemic stroke |
| 投稿时间：2023-02-28 |
| DOI：10.3969/J.issn.1672-6790.2023.02.003 |
| 中文关键词: 卒中 微RNAs 缺氧诱导因子1,α亚基 缺氧缺血,脑 综述 |
| 英文关键词: Stroke MicroRNAs Hypoxia-inducible factor 1,alpha subunit Hypoxia-ischemia,brain Review 〖FL |
| 基金项目: |
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| 中文摘要: |
| 缺血性脑卒中是我国成年人致残和死亡的主要原因之一,可导致脑细胞和组织缺血缺氧性损害,引发机体神经功能障碍。其病因复杂,发病率高,预后差,一直是临床医学研究的重点。然而,目前脑卒中治疗方法仍然有限,机制尚且不明。MicroRNA-210是一种短核苷酸链,以转录后的方式调节蛋白质表达,具有治疗缺血性脑卒中的潜力。在神经细胞中,MicroRNA-210参与缺血性脑卒中的抗炎症反应、抗凋亡作用、抑制氧化应激、促进神经元可塑性和血管生成,发挥神经保护作用,这将为缺血性脑卒中的治疗提供有效靶点和干预策略。 |
| 英文摘要: |
| Ischemic stroke is one of the main causes of disability and death in adults in China,which can lead to ischemic and hypoxic damage of brain cells and tissues,and cause neurological dysfunction.Its complex etiology,high incidence and poor prognosis have always been the focus of clinical medical research.However,the treatment of stroke is still limited,and the research mechanism is still unknown.MicroRNA-210 is a short nucleotide chain that regulates protein expression in a post-transcriptional manner and has the potential to treat ischemic stroke.In neurocytes,MicroRNA-210 is involved in the anti-inflammatory response,anti-apoptotic effect,inhibition of oxidative stress,promotion of neuronal plasticity and angiogenesis in ischemic stroke,and exerts neuroprotective effects,which will provide effective targets and intervention strategies for the treatment of ischemic stroke. |
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