| 虞松平,黄童,王骥,杨柳,郭勇娟.肺小结节的健康管理问题研究[J].中国临床保健杂志,2023,26(3):388-391. |
| 肺小结节的健康管理问题研究 |
| Study on health management of pulmonary small nodules |
| 投稿时间：2023-04-18 |
| DOI：10.3969/J.issn.1672-6790.2023.03.023 |
| 中文关键词: 多发性肺结节 健康促进 危险因素 随访研究 精准医学 |
| 英文关键词: Multiple pulmonary nodules Health promotion Risk factors Follow-up studies Precision medicine 〖FL |
| 基金项目:浙江省医药卫生科技计划项目(2020ZH032);高端质谱技术和临床应用浙江省工程研究中心开放基金项目(zyk2207);宁波市自然科学基金项目(2019A610339) |
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| 中文摘要: |
| 目的 探讨良恶性肺小结节的危险因素,提高肺小结节健康管理水平。方法 收集宁波市第一医院2020年1月至2021年2月手术切除的肺小结节临床、影像及病理资料。回顾性分析良、恶性2组间的特征及危险因素；查找小结节管理中的不足。结果 1 062例手术切除肺小结节中,良性336例,恶性726例；随访时间≥3个月者共685例,其中404例在本院有2次或以上胸部CT对照。单因素危险因素分析,性别、结节类型、结节最大径、结节增大或实变等在良恶性组间差异有统计学意义(P＜0.05)。多因素logistic回归分析,女性(OR=1.759,95%CI:1.076~2.877)、非实性结节(OR=18.914,95%CI:7.768~46.054)、结节较大者(OR=1.333,95%CI:1.156~1.536)、结节增大(OR=3.815,95%CI:1.688~8.622)是恶性肿瘤的危险因素。3例出现转移或直接侵犯。结论 女性、非实性肺小结节、直径较大者、结节增大是恶性肿瘤的危险因素,应规范全程管理。 |
| 英文摘要: |
| Objective To explore the risk factors for benign and malignant pulmonary nodules,and improve the health management level of pulmonary nodules.Methods This was a retrospective case-control study of 1 062 patients who had undergone pulmonary small nodule resection at the Ningbo First Hospital from January 2020 to February 2021.Patients′ demographic characteristics,follow-up time,clinical features,computed tomography findings and pathological diagnosis were collected.The characteristics were compared between the benign and malignant groups.Find deficiencies in the management of lung small nodules.Results A total of 1 062 cases were included:336 with benign and 726 with malignant nodules.685 cases were followed up for more than 3 months,of which 404 cases had two or more chest CT examinations.The analysis showed that gender,nodule type,nodule maximum diameter,and nodule growth (enlargement in the nodule size or development of a new solid component) were statistically significant between the benign and malignant groups (P<0.05).In a multivariate logistic regression analysis,female (OR=1.759,95%CI:1.076-2.877),subsolid nodule (OR=18.914,95%CI:7.768-46.054),nodule maximum diameter (OR=1.333,95%CI:1.156-1.536),enlargement in the nodule size(OR=3.815,95%CI:1.688-8.622) were significant risk factors for malignancy.Metastasis or invasion occurred in 3 cases.Conclusions Female,subsolid nodule,nodule maximum diameter,enlargement in the nodule size are significant risk factors for malignancy. |
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