| 刘乾泰,马艳,刘乃鹏,李甜甜,孙梦雯,胡晓文.结缔组织病相关间质性肺疾病患者生活质量的影响因素分析[J].中国临床保健杂志,2023,26(6):803-809. |
| 结缔组织病相关间质性肺疾病患者生活质量的影响因素分析 |
| Analysis on the influencing factors of quality of life in patients with connective tissue disease-associated interstitial lung disease |
| 投稿时间：2023-09-19 |
| DOI：10.3969/J.issn.1672-6790.2023.06.020 |
| 中文关键词: 肺疾病,间质性 结缔组织疾病 生活质量 危险因素 |
| 英文关键词: Lung diseases,interstitial Connective tissue diseases Quality of life Risk factors 〖FL |
| 基金项目: |
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| 中文摘要: |
| 目的 回顾性分析结缔组织病相关间质性肺疾病(CTD-ILD)患者生活质量,探索影响患者生活质量的相关因素。方法 选取2022年11月至2023年8月中国科学技术大学附属第一医院(安徽省立医院)风湿免疫科的部分CTD-ILD住院患者(CTD-ILD组)及同时期体检健康者(健康对照组),对2组人群进行问卷调查,并分析CTD-ILD患者相关资料。通过多元线性回归分析CTD-ILD患者生活质量的影响因素。结果 最终共纳入86例CTD-ILD患者及57例健康对照者,2组人群基线资料差异无统计学意义(P＞0.05)。CTD-ILD组健康状况调查问卷(SF-36)中生理健康总分(PCS)、心理健康总分(MCS)得分及世界卫生组织生活质量测定量表简表(WHOQOL-BREF)各领域得分与健康对照组相比均较低,差异有统计学意义(P＜0.05)。单因素分析显示不同性别、年龄、居住地、文化程度、医保类型、病程、近1年住院次数以及伴或不伴疼痛的CTD-ILD患者,生活质量差异有统计学意义(P＜0.05)。Spearman相关性分析显示,SF-36中PCS、MCS得分及WHOQOL-BREF各领域得分与改良版医学研究委员会呼吸困难问卷(mMRC)分级均呈负相关(r=-0.466~-0.271,P＜0.05)；SF-36中PCS得分及WHOQOL-BREF各领域得分与查尔森共病指数(CCI)均呈负相关(r=-0.422~-0.273,P＜0.05)；SF-36中PCS得分及WHOQOL-BREF中生理领域、心理领域、环境领域得分与Barthel指数均呈正相关(r=0.261～0.445,P＜0.05)。多元线性回归结果显示,性别、年龄、居住地、文化程度、疼痛、近1年住院次数、mMRC分级、CCI、Barthel指数为CTD-ILD患者生活质量的独立影响因素(P＜0.05)。结论 CTD-ILD患者生活质量较低；女性、年龄≥45岁、居住于农村、文化程度较低、呼吸困难程度较重、疼痛、共病情况较严重、日常生活能力较差以及近1年住院次数较多为CTD-ILD患者生活质量下降的重要影响因素。 |
| 英文摘要: |
| Objective To retrospectively analyze the quality of life in patients with connective tissue disease-associated interstitial lung disease (CTD-ILD) and explore the influencing factors of their quality of life.Methods A questionnaire survey was conducted on a group of inpatients with CTD-ILD from department of rheumatology and immunology in the First Affiliated Hospital of University of Science and Technology of China from November,2022 to August,2023 (classified as the CTD-ILD group),along with a healthy control group consisting of some healthy individuals residing during the same period.The relevant data of CTD-ILD patients were analyzed and the factors influencing their quality of life were examined through multiple linear regression analysis.Results A total of 86 CTD-ILD patients and 57 healthy controls were ultimately enrolled,and no significant differences were observed in the baseline characteristics between the two groups (P>0.05).The physical component summary (PCS) and mental component summary (MCS) scores in The MOS 36-Item Short-Form Health Survey (SF-36),as well as the scores of each domain of World Health Organization Quality of Life-Brief Version (WHOQOL-BREF),were lower in the CTD-ILD group compared with those in the healthy control group,and the difference was statistically significant (P<0.05).Univariate analysis showed significant differences in the quality of life in CTD-ILD patients among gender,age,place of residence,education attainment,type of medical insurance,duration of illness,number of hospitalizations within the previous year,and presence or absence of pain (P<0.05).Spearman correlation analysis showed that PCS,MCS scores,and scores in each domain of WHOQOL-BREF were negatively correlated with the modified Medical Research Council (mMRC) grades (r=-0.466--0.271,P<0.05).PCS scores and scores in each domain of WHOQOL-BREF exhibited a negative correlation with Charlson comorbidity index (CCI) (r=-0.422--0.273,P<0.05).PCS scores and scores in the physical,psychological,and environment domains of WHOQOL-BREF were positively correlated with the Barthel Index (r=0.261-0.445,P<0.05).The results of the multiple linear regression analysis demonstrated that gender,age,place of residence,education attainment,pain,number of hospitalizations in the previous year,mMRC grades,CCI and Barthel index were the independent influencing factors for the quality of life in CTD-ILD patients (P<0.05).Conclusions The quality of life in CTD-ILD patients is reduced.Female,age ≥ 45 years old,residence in rural areas,lower educational attainment,severe dyspnea,pain,severe comorbidity,poor activities of daily living,and increased hospitalizations within the previous year are important influencing factors for the decline of the quality of life in CTD-ILD patients. |
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